Department of Neurology, New York University Langone Medical Center, New York, NY, USA.
Arch Clin Neuropsychol. 2013 Dec;28(8):837-44. doi: 10.1093/arclin/act057. Epub 2013 Jul 17.
Current diagnostic criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) require standardized tests that are capable of measuring a range of neurocognitive abilities in healthy elderly individuals and sensitive to detect change over time. There currently is no clearly-established "gold standard" for this purpose. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a widely used neuropsychological test battery for the clinical diagnosis/tracking of dementia also recently incorporated into clinical trials of new investigational medications for AD treatment. The RBANS has a number of design features that suggest possible utility in diagnosis/tracking of MCI. Eighty-one patients with MCI completed the RBANS and their scores were compared with 81 demographically matched healthy controls. RBANS Total Scale scores in both groups were normally distributed, demonstrating no floor/ceiling effects. The MCI group was most impaired on the Delayed Memory Index (DMI). Receiver operating characteristic analyses reflected good discrimination, with an area under the curve of 0.88 for the Total Scale score and 0.90 for the DMI score. The profile of performance for the MCI group was similar to that previously reported for mild AD patients. The RBANS may be a suitable neurocognitive battery for the detection and tracking of MCI presumed to be due to AD.
目前，阿尔茨海默病（AD）所致轻度认知障碍（MCI）的诊断标准需要使用能够测量健康老年人一系列神经认知能力的标准化测试，并且能够敏感地检测随时间的变化。目前，尚无明确的“金标准”用于此目的。重复性成套神经心理状态测验（RBANS）是一种广泛用于痴呆症临床诊断/跟踪的神经心理学测试组合，最近也被纳入 AD 治疗新研究药物的临床试验中。RBANS 具有许多设计特点，表明其在 MCI 的诊断/跟踪方面可能具有一定的实用性。81 名 MCI 患者完成了 RBANS，将他们的得分与 81 名年龄匹配的健康对照组进行比较。两组的 RBANS 总量表得分均呈正态分布，无地板/天花板效应。MCI 组在延迟记忆指数（DMI）上受损最严重。受试者工作特征分析反映出良好的区分度，总量表得分的曲线下面积为 0.88，DMI 得分的曲线下面积为 0.90。MCI 组的表现特征与先前报道的轻度 AD 患者相似。RBANS 可能是一种适合检测和跟踪 AD 所致 MCI 的神经认知测试组合。
