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罗勒提取物对镉诱导的白化大鼠睾丸组织形态计量学和免疫组化改变的影响。

Effect of Ocimum basilicum extract on cadmium-induced testicular histomorphometric and immunohistochemical alterations in albino rats.

作者信息

Sakr Saber A, Nooh Hanna Z

机构信息

Department of Zoology, Faculty of Science, Menoufia University, Shebin El-kom, Egypt.

出版信息

Anat Cell Biol. 2013 Jun;46(2):122-30. doi: 10.5115/acb.2013.46.2.122. Epub 2013 Jun 30.

DOI:10.5115/acb.2013.46.2.122
PMID:23869259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3713276/
Abstract

The present study examined the efficacy of Ocimum basilicum (basil) extract, a natural herb, with antioxidant properties, against testicular toxicity induced by cadmium (Cd), which is one of the most important toxic heavy metals. The intoxicated rats showed significant alterations in the testicular tissue including decreased seminiferous epithelium height and changes in the arrangement of spermatogenic layers. Hypospermatogensis with cytoplasmic vacuolization and pyknotic nuclei were observed. Intertubular hemorrahage and absence of spermatozoa were noted. Decreased cell proliferation was reflected by a decrease in Ki-67 expression, whereas the increase in apoptotic rate was associated with a decrease in the Bcl/Bax ratio. Concomitant treatment with aqueous basil extract led to an improvement in histological, morphometrical and immunohistochemical changes induced by Cd. The beneficial effects of basil extract could be attributed to its antioxidant properties.

摘要

本研究考察了具有抗氧化特性的天然草药罗勒提取物对镉（Cd）诱导的睾丸毒性的疗效，镉是最重要的有毒重金属之一。中毒大鼠的睾丸组织出现明显改变，包括生精上皮高度降低和生精层排列变化。观察到精子发生减少伴有细胞质空泡化和细胞核固缩。注意到管间出血和无精子。Ki-67表达降低反映细胞增殖减少，而凋亡率增加与Bcl/Bax比值降低有关。罗勒水提取物联合治疗可改善镉诱导的组织学、形态计量学和免疫组化变化。罗勒提取物的有益作用可能归因于其抗氧化特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b4f/3713276/f37b89e01471/acb-46-122-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b4f/3713276/3642b741759b/acb-46-122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b4f/3713276/500f7d89842b/acb-46-122-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b4f/3713276/90191d5b6d6d/acb-46-122-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b4f/3713276/89a9c938338d/acb-46-122-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b4f/3713276/f37b89e01471/acb-46-122-g006.jpg

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J Hum Reprod Sci. 2012 Jan;5(1):37-42. doi: 10.4103/0974-1208.97798.
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