Department of Dermatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
Contact Dermatitis. 2013 Aug;69(2):112-7. doi: 10.1111/cod.12041.
Physicians need a simple, disease-specific tool with which to assess disease severity and the effect of therapeutic intervention in patients with chronic hand eczema. The currently available clinical scoring systems include numerous items, which makes them laborious to complete and limit their use in daily practice.
To develop a simple tool with which to assess disease severity of patients with chronic hand eczema.
We evaluated two tools, the Hand Eczema Severity Index (HECSI) and the Hand Eczema Area and Severity score, to determine their ability to predict the Investigator's Global Assessment (IGA) of disease severity in patients with moderate to severe hand eczema. We used a stepwise reduction analysis to determine a minimal set of significantly contributing items for predicting IGA.
A three-item score, based on the highest observed value of induration, fissuring, and scaling, predicted IGA with a correlation of 0.667. The HECSI predicted the IGA with a correlation of 0.675.
On the basis of this analysis, we propose a simple tool for clinical decision-making and evaluation of therapeutic intervention in daily practice.
医生需要一种简单的、针对特定疾病的工具，用以评估慢性手部湿疹患者的疾病严重程度和治疗干预效果。目前可用的临床评分系统包括许多项目，这使得它们的完成过程繁琐，限制了它们在日常实践中的应用。
开发一种简单的工具，用以评估慢性手部湿疹患者的疾病严重程度。
我们评估了两种工具，即手部湿疹严重指数（HECSI）和手部湿疹面积和严重程度评分，以确定它们在预测中度至重度手部湿疹患者的研究者整体评估（IGA）方面的能力。我们使用逐步减少分析来确定用于预测 IGA 的最小一组具有显著贡献的项目。
基于硬结、皲裂和鳞屑的最高观察值的三项评分，预测 IGA 的相关性为 0.667。HECSI 预测 IGA 的相关性为 0.675。
基于这项分析，我们提出了一种简单的工具，用于临床决策和日常实践中治疗干预的评估。
