Goutorbe Philippe, Daranda Erwan, Asencio Yves, Esnault Pierre, Prunet Bertrand, Bordes Julien, Palmier Bruno, Meaudre Eric
Emergency, Anesthesia and ICU Departement, Military Teaching Hospital Sainte Anne, Boulevard Sainte Anne, Toulon 83000, France.
BMC Res Notes. 2013 Jul 21;6:282. doi: 10.1186/1756-0500-6-282.
Long term oxygen therapy improves survival in hypoxemic patients with chronic obstructive pulmonary disease (COPD). Because pressure support ventilation with a home care ventilator is largely unsupervised, there is considerable risk of leakage occurring, which could affect delivered FiO2. We have therefore conducted a bench study in order to measure the effect of different levels of O2 supply and degrees of leakage on delivered FiO2. Ventilator tested: Legendair® (Airox™, Pau, France). Thirty-six measures were performed in each four ventilators with zero, 5 and 10 l.min-1 leakage and 1,2,4 and 8 l O2 flow.
FiO2 decreased significantly with 5 l.min-1 leakage for all O2 flow rates, and with 10 l.min-1 at 4 and 8 l.min-1 O2.
During application of NIV on home ventilators, leakage can dramatically decrease inspired FiO2 making it less effective. It is important to know the FiO2 dispensed when NIV is used for COPD at home. We would encourage industry to develop methods for FiO2 regulation Chronic use of NIV for COPD with controlled FiO2 or SpO2 requires further studys.
长期氧疗可提高慢性阻塞性肺疾病（COPD）低氧血症患者的生存率。由于家庭护理呼吸机的压力支持通气在很大程度上缺乏监督，存在相当大的漏气风险，这可能会影响输送的FiO2。因此，我们进行了一项实验台研究，以测量不同水平的氧气供应和漏气程度对输送的FiO2的影响。测试的呼吸机：Legendair®（Airox™，法国波城）。在四台呼吸机上分别进行了三十六次测量，漏气量分别为零、5和10升/分钟，氧气流量分别为1、2、4和8升/分钟。
对于所有氧气流量，漏气量为5升/分钟时FiO2显著下降，氧气流量为4和8升/分钟且漏气量为10升/分钟时FiO2也显著下降。
在家用呼吸机上应用无创通气（NIV）期间，漏气可显著降低吸入的FiO2，使其效果降低。在家中对COPD患者使用NIV时，了解输送的FiO2很重要。我们鼓励行业开发调节FiO2的方法。对COPD患者长期使用FiO2或脉搏血氧饱和度（SpO2）受控的NIV需要进一步研究。
