Polymer Materials Research Department, Institute of Advanced Technology and New Material, City of Scientific Research and Technology Applications, New Borg El-Arab City, 21934, Alexandria, Egypt,
Appl Biochem Biotechnol. 2013 Oct;171(3):643-54. doi: 10.1007/s12010-013-0395-8. Epub 2013 Jul 20.
Nanotechnology is expected to open some new aspects to fight and prevent diseases using atomic-scale tailoring of materials. The main aim of this study is to biosynthesize silver nanoparticles (AgNPs) using Trichoderma viride (HQ438699); the metabolite of this fungus will help either in reduction of the silver nitrate-adding active materials which will be loaded on the surface of the produced AgNPs. Poly(acrylonitrile-co-methyl methacrylate) copolymer (poly (AN-co-MMA)) was grafted with the prepared AgNPs. The poly(AN-co-MMA)/AgNPs were examined against ten different pathogenic bacterial strains, and the result was compared with another four different generic antibiotics. The produced poly(AN-co-MMA)/AgNPs showed high antibacterial activity compared with the four standard antibiotics. Moreover, the grafting of these AgNPs into the copolymer has potential application in the biomedical field.
纳米技术有望通过对材料进行原子级别的剪裁，开辟一些新的领域来对抗和预防疾病。本研究的主要目的是利用绿色木霉（HQ438699）生物合成银纳米粒子（AgNPs）；真菌的代谢产物将有助于减少添加到表面的硝酸银活性材料，这些活性材料将负载在生成的 AgNPs 上。聚丙烯腈-共-甲基丙烯酸甲酯共聚物（poly(AN-co-MMA)）接枝了制备好的 AgNPs。poly(AN-co-MMA)/AgNPs 被检测对十种不同的致病菌菌株的抗菌活性，结果与另外四种不同的普通抗生素进行了比较。与四种标准抗生素相比，生成的 poly(AN-co-MMA)/AgNPs 显示出更高的抗菌活性。此外，将这些 AgNPs 接枝到共聚物中在生物医学领域有潜在的应用。
