Vayndorf Elena M, Lee Siu Sylvia, Liu Rui Hai
Institute of Comparative and Environmental Toxicology, Cornell University, Ithaca, NY.
J Funct Foods. 2013 Jul;5(3):1236-1243. doi: 10.1016/j.jff.2013.04.006.
Regular consumption of fruits and vegetables is associated with reduced risk of age-related functional decline and chronic diseases such as cancer and cardiovascular disease. These effects are primarily attributed to phytochemicals, plant compounds with a wide range of biological activities and health benefits. Apples, the top contributor of fruit phenolics in American diets, have high antioxidant, antiproliferative and chemopreventive activity and However, little is known about their effects on aging. The objectives of this study were to determine the effects of whole apple phytochemical extracts on lifespan, healthspan and resistance to various stresses using as a model. The mean and maximum lifespan of animals treated with 2.5, 5 and 10 mg/ml whole apple extracts increased significantly in a dose-dependent manner by up to 39 and 25%, respectively. Healthspan also significantly improved as indicated by improved motility and reduced lipofuscin accumulation. Animals pre-treated with whole apple extracts were more resistant to stresses such as heat, UV radiation, paraquat-induced oxidative stress, and pathogenic infection, suggesting that cellular defense and immune system functions also improved. Our findings indicate that, in , whole apple extracts slow aging, extend lifespan, improve healthspan, and enhance resistance to stress.
经常食用水果和蔬菜与降低与年龄相关的功能衰退风险以及患癌症和心血管疾病等慢性疾病的风险有关。这些作用主要归因于植物化学物质，即具有广泛生物活性和健康益处的植物化合物。苹果是美国饮食中水果酚类物质的主要来源，具有高抗氧化、抗增殖和化学预防活性，然而，人们对其对衰老的影响知之甚少。本研究的目的是以[具体动物]为模型，确定全苹果植物化学提取物对寿命、健康寿命和对各种应激的抵抗力的影响。用2.5、5和10毫克/毫升全苹果提取物处理的动物的平均寿命和最大寿命分别以剂量依赖的方式显著增加，最高可达39%和25%。如运动能力改善和脂褐素积累减少所示，健康寿命也显著改善。用全苹果提取物预处理的动物对热、紫外线辐射、百草枯诱导的氧化应激和病原体感染等应激更具抵抗力，这表明细胞防御和免疫系统功能也得到了改善。我们的研究结果表明，在[具体动物]中，全苹果提取物可延缓衰老、延长寿命、改善健康寿命并增强应激抵抗力。
