Dept. of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Parasitol. 2013 Oct;43(11):875-7. doi: 10.1016/j.ijpara.2013.06.008. Epub 2013 Jul 26.
The present study investigates the molecular characteristics of cerebral Echinococcus cysts. A total of 10 specimens of cerebral Echinococcus cysts, including six formalin-fixed paraffin blocks and four intact cerebral cysts, were used for this study. The target DNA was successfully amplified from eight samples and sequenced. BLAST analysis indicated that sequenced isolates belong to the Echinococcus granulosus (G6) genotype. All of the eight sampled brain cysts belonged to the G6 genotype, while all of the eight liver cysts belonged to G1. This is a strong indication that G6 has a higher affinity for the human brain than G1.
本研究调查了脑包虫囊肿的分子特征。共使用了 10 个脑包虫囊肿标本，包括 6 个福尔马林固定石蜡块和 4 个完整的脑囊肿，用于本研究。从 8 个样本中成功扩增出目标 DNA 并进行了测序。BLAST 分析表明，测序分离株属于细粒棘球蚴（G6）基因型。所有 8 个采样脑囊肿均属于 G6 基因型，而所有 8 个肝囊肿均属于 G1。这强烈表明 G6 比 G1 对人脑具有更高的亲和力。
