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氧化锌纳米粒子的合成及其抗氧化和细胞毒性活性评价。

Synthesis of ZnO nanoparticles and evaluation of antioxidant and cytotoxic activity.

机构信息

Department of Chemical Sciences, India.

Department of Physics, India.

出版信息

Colloids Surf B Biointerfaces. 2013 Nov 1;111:556-60. doi: 10.1016/j.colsurfb.2013.06.041. Epub 2013 Jul 5.

Abstract

ZnO nanoparticles were synthesized by thermal decomposition method and were characterized by UV-vis spectroscopy, XRD, SEM, EDX and TEM analysis. The resultant nanoparticles are nearly spherical and size is in the range of 40-50 nm. The antioxidant behavior of ZnO nanoparticles was assessed by scavenging free radicals of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) with varying nanoparticle concentration and time interval individually. The DPPH scavenging activity was monitored by UV-vis spectrophotometer. ZnO nanoparticles were also showing cytotoxic activity which was studied by hemolytic potentiality test.

摘要

氧化锌纳米粒子通过热分解法合成,并通过紫外-可见光谱、XRD、SEM、EDX 和 TEM 分析进行了表征。所得纳米粒子几乎呈球形,尺寸在 40-50nm 范围内。通过单独改变纳米粒子浓度和时间间隔来评估 ZnO 纳米粒子对 2,2-二苯基-1-苦肼基自由基(DPPH)的清除自由基行为。通过紫外-可见分光光度计监测 DPPH 清除活性。还通过溶血潜能试验研究了 ZnO 纳米粒子的细胞毒性活性。

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