Molecular Pharmacology and Chemistry Program, Departments of Medicine and Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Adv Drug Deliv Rev. 2013 Dec;65(15):2016-22. doi: 10.1016/j.addr.2013.07.013. Epub 2013 Jul 27.
Carbon nanotubes display characteristics that are potentially useful in their development as scaffolds for vaccine compositions. These features include stability in vivo, lack of intrinsic immunogenicity, low toxicity, and the ability to be appended with multiple copies of antigens. In addition, the particulate nature of carbon nanotubes and their unusual properties of rapid entry into antigen-presenting cells, such as dendritic cells, make them especially useful as carriers of antigens. Early attempts demonstrating carbon nanotube-based vaccines can be used in both infectious disease settings and cancer are promising.
碳纳米管具有一些特性，这些特性可能使其在作为疫苗成分的支架方面具有潜力。这些特性包括在体内的稳定性、缺乏固有免疫原性、低毒性以及能够附加多个抗原拷贝。此外，碳纳米管的颗粒性质及其进入抗原呈递细胞（如树突状细胞）的异常快速的特性，使它们成为抗原载体的特别有用。早期的基于碳纳米管的疫苗的尝试可以在传染病和癌症的治疗中都有应用，这些尝试是有前途的。
