BLK Super Speciality Hospital, Pusa Road, New Delhi, 110005, India,
Curr Infect Dis Rep. 2013 Oct;15(5):432-9. doi: 10.1007/s11908-013-0356-y.
Cutaneous herpes zoster is a benign, localized painful skin lesion, more common in the elderly and immunocompromised population across the globe. It is caused by reactivation of the varicella zoster virus lying dormant in the dorsal root ganglion. Although self-limiting in nature, it can cause protean complications in the vulnerable patient. The advent of antiviral therapy and an FDA-approved vaccine has reduced the morbidity of the disease considerably. However, focused research on the disease-modulating factors and prevention in the immunocompromised are still issues that warrant research. The current understanding of cutaneous herpes zoster and its pathogenesis, complications, and management are discussed in this review.
带状疱疹是一种良性、局限性的疼痛性皮肤损伤,在全球范围内更常见于老年人和免疫功能低下人群。它是由潜伏在背根神经节中的水痘带状疱疹病毒重新激活引起的。虽然其自然病程是自限性的,但它可能会给脆弱的患者带来多种并发症。抗病毒治疗和美国食品药品监督管理局批准的疫苗的出现,大大降低了该病的发病率。然而,针对免疫功能低下患者的疾病调节因素和预防措施的研究仍然是需要关注的问题。本综述讨论了带状疱疹及其发病机制、并发症和治疗的当前认识。