通过pH缓冲减轻皮内注射利多卡因的疼痛。
Reducing the pain of intradermal lignocaine injection by pH buffering.
作者信息
McGlone R, Bodenham A
机构信息
Accident and Emergency Department, Pinderfields Hospital, Wakefield, England.
出版信息
Arch Emerg Med. 1990 Jun;7(2):65-8. doi: 10.1136/emj.7.2.65.
Abstract
The effect of pH on the pain of administration and efficacy of 1% lignocaine was investigated in a prospective, double-blind, randomized study of 20 adult volunteers. Onset and spread of anaesthesia by intra-dermal injection were not altered, but there was a significant reduction in pain scores with a higher pH. Overall, pain scores appear to be more dependent on the speed of injection rather than alteration of pH.
摘要
在一项针对20名成年志愿者的前瞻性、双盲、随机研究中，研究了pH值对1%利多卡因给药疼痛及疗效的影响。皮内注射麻醉的起效和扩散未受影响，但较高pH值时疼痛评分显著降低。总体而言，疼痛评分似乎更多地取决于注射速度而非pH值的改变。
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本文引用的文献
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Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.局部麻醉药：药物-受体反应的亲水和疏水途径。
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