Todd I C, Ballantyne D
Victoria Infirmary, Glasgow.
Br Heart J. 1990 Jul;64(1):14-9. doi: 10.1136/hrt.64.1.14.
Forty men with chronic stable angina and no prior myocardial infarction were studied. Exercise tolerance testing was carried out off treatment and after beta blockade. beta Blockers were stopped and the patients were randomised to a control group and a study group of patients who undertook a one year high intensity training programme. The groups were then restudied. Submaximum heart rate was reduced by 13 beats per minute by training and by 23 beats per minute by atenolol. Training increased the maximum heart rate by 10 beats per minute and atenolol reduced it by 29 beats per minute. The double produce ST threshold was increased from 183 to 205 by training but reduced to 143 by atenolol. Maximum ST depression was similarly reduced by both training and atenolol. As a result of the effects on maximum heart rate, training produced a greater improvement in exercise tolerance than atenolol with a treadmill time increased from 741 seconds to 1272 seconds with training compared with 974 seconds with atenolol. Other variables were similarly affected. Thus the antianginal efficacy of exercise training is as good as that achieved by beta blockade and represents an alternative to such treatment.
对40名患有慢性稳定型心绞痛且既往无心肌梗死的男性进行了研究。在未治疗时以及使用β受体阻滞剂后进行运动耐量测试。停用β受体阻滞剂后，将患者随机分为对照组和研究组，研究组患者进行为期一年的高强度训练计划。之后对两组进行再次研究。通过训练，亚极量心率每分钟降低13次，而阿替洛尔使其降低23次。训练使最大心率每分钟增加10次，阿替洛尔使其降低29次。训练使双倍乘积ST段阈值从183提高到205，而阿替洛尔使其降至143。训练和阿替洛尔均同样降低了最大ST段压低。由于对最大心率的影响，训练比阿替洛尔在运动耐量方面产生了更大的改善，训练使跑步机运动时间从741秒增加到1272秒，而阿替洛尔为974秒。其他变量也受到类似影响。因此，运动训练的抗心绞痛疗效与β受体阻滞剂相当，可作为此类治疗的替代方法。
