维生素 E 在肺部的两面性。
Two faces of vitamin E in the lung.
机构信息
Allergy-Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
出版信息
Am J Respir Crit Care Med. 2013 Aug 1;188(3):279-84. doi: 10.1164/rccm.201303-0503ED.
Abstract
Asthma and allergic lung disease occur as complex environmental and genetic interactions. Clinical studies of asthma indicate a number of protective dietary factors, such as vitamin E, on asthma risk. However, these studies have had seemingly conflicting outcomes. In this perspective, we discuss opposing regulatory effects of tocopherol isoforms of vitamin E, mechanisms for tocopherol isoform regulation of allergic lung inflammation, association of vitamin E isoforms with outcomes in clinical studies, and how the variation in global prevalence of asthma may be explained, at least in part, by vitamin E isoforms.
摘要
哮喘和过敏性肺部疾病是复杂的环境和遗传相互作用的结果。哮喘的临床研究表明，一些保护性的饮食因素，如维生素 E，会影响哮喘的发病风险。然而，这些研究的结果似乎存在矛盾。在这篇观点文章中，我们讨论了维生素 E 的生育酚异构体的相反的调节作用、生育酚异构体调节过敏性肺炎症的机制、维生素 E 异构体与临床研究结果的关联，以及维生素 E 异构体如何至少部分解释了哮喘在全球的流行率差异。
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