遗传性单击事件定义癌症预防？
Heritable one-hit events defining cancer prevention?
机构信息
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Cell Cycle. 2013 Aug 15;12(16):2553-7. doi: 10.4161/cc.25690. Epub 2013 Jul 29.
Abstract
Over 100 years ago (1902-1914) Theodor Boveri suggested a role for mutations in cancer. Boveri's ideas were derived from the then "just-emerging" chromosome theory of inheritance. While demonstrating chromosomal aberrations as a cause of genetic imbalance, Boveri suggested that possible causes of malignancy may include events such as aneuploidy that are now defined as gene mutations, asserting all the while that malignancy occurs at the cellular level. Indeed, studies to date essentially uniformly show that cancer is a genetic disease.
摘要
100 多年前（1902-1914 年），西奥多·博韦里（Theodor Boveri）提出了突变在癌症中的作用。博韦里的想法源自当时刚刚出现的染色体遗传理论。在证明染色体异常是遗传失衡的原因的同时，博韦里认为恶性肿瘤的可能原因可能包括非整倍体等现在被定义为基因突变的事件，并一直断言恶性肿瘤发生在细胞水平。事实上，迄今为止的研究基本上一致表明，癌症是一种遗传性疾病。
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