长圆形山蚂蝗中的三种新的C-烷基化黄酮类化合物。
Three new C-alkylated flavonoids from Desmodium oblongum.
作者信息
Li Yan-Ping, Hu Qiu-Fen, Rao Gao-Xiong
机构信息
a College of Pharmaceutic Science , Yunnan University of Traditional Chinese Medicine , Kunming 650500 , China.
b Engineering Laboratory for National Healthcare Theories and Products of Yunnan Province , Yunnan University of Nationalities , Kunming 650031 , China.
出版信息
J Asian Nat Prod Res. 2017 Oct;19(10):954-959. doi: 10.1080/10286020.2017.1285910. Epub 2017 Feb 1.
Three new C-alkylated flavonoids, 4'-hydroxy-8-isobutyryl-7-methoxy-6-methyl-flavone (1), 4',7-dimethoxy-8-isobutyryl-6-methyl-flavone (2), and 4',7-dimethoxy-8-isobutyryl-flavone (3), together with three know ones luteolin (4), kaemferol (5), and quercetin (6), were isolated from Desmodium oblongum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 showed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC values of 8.5, 6.5, and 7.8 μM; compound 2 showed cytotoxicity against SHSY5Y and PC3 cell lines with IC values of 5.0 and 6.8 μM; compound 3 displayed cytotoxicity against SHSY5Y and MCF7 cell lines with IC values of 6.4 and 9.4 μM, respectively.
从长圆形山蚂蝗中分离出三种新的C-烷基化黄酮类化合物，即4'-羟基-8-异丁酰基-7-甲氧基-6-甲基黄酮（1）、4',7-二甲氧基-8-异丁酰基-6-甲基黄酮（2）和4',7-二甲氧基-8-异丁酰基黄酮（3），以及三种已知化合物木犀草素（4）、山奈酚（5）和槲皮素（6）。通过光谱方法，包括广泛的一维和二维核磁共振技术对它们的结构进行了阐明。化合物1对NB4、SHSY5Y和MCF7细胞系显示出细胞毒性，IC值分别为8.5、6.5和7.8 μM；化合物2对SHSY5Y和PC3细胞系显示出细胞毒性，IC值分别为5.0和6.8 μM；化合物3对SHSY5Y和MCF7细胞系显示出细胞毒性，IC值分别为6.4和9.4 μM。
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