• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

诱导多能干细胞分化为人类生殖细胞的研究引发的伦理和法律问题。

Ethical and legal issues arising in research on inducing human germ cells from pluripotent stem cells.

机构信息

Office of Health and Safety, Hokkaido University, Sapporo 060-0808, Japan.

出版信息

Cell Stem Cell. 2013 Aug 1;13(2):145-8. doi: 10.1016/j.stem.2013.07.005.

DOI:10.1016/j.stem.2013.07.005
PMID:23910081
Abstract

Derivation of eggs or sperm from pluripotent stem cells or direct reprogramming from somatic cells would have huge effects on assisted reproductive technology. Here we discuss important ethical, legal, and social issues that would be raised by the development of such female or male gametes for clinical use.

摘要

从多能干细胞中提取卵子或精子,或直接从体细胞中重新编程,将对辅助生殖技术产生巨大影响。在这里,我们讨论了开发此类用于临床使用的雌性或雄性配子所引发的重要伦理、法律和社会问题。

相似文献

1
Ethical and legal issues arising in research on inducing human germ cells from pluripotent stem cells.诱导多能干细胞分化为人类生殖细胞的研究引发的伦理和法律问题。
Cell Stem Cell. 2013 Aug 1;13(2):145-8. doi: 10.1016/j.stem.2013.07.005.
2
Recommended Ethical Safeguards on Fertilization of Human Germ Cells Derived from Pluripotent Stem Cells Solely for Research Purposes.推荐的人类多能干细胞来源的生殖细胞仅用于研究目的的受精的伦理安全措施。
Stem Cell Rev Rep. 2016 Aug;12(4):377-84. doi: 10.1007/s12015-016-9666-4.
3
Alternative sources of pluripotent stem cells: ethical and scientific issues revisited.替代性多能干细胞来源:伦理和科学问题再探讨。
Stem Cells Dev. 2010 Aug;19(8):1121-9. doi: 10.1089/scd.2009.0482.
4
Pluripotent stem cell-derived gametes: truth and (potential) consequences.多能干细胞衍生配子:真相与(潜在)后果。
Cell Stem Cell. 2009 Jul 2;5(1):11-4. doi: 10.1016/j.stem.2009.06.005.
5
[Ethical reflections on cell reprogramming].[关于细胞重编程的伦理思考]
Cuad Bioet. 2012 May-Aug;23(78):287-99.
6
In Vitro Gamete Differentiation from Pluripotent Stem Cells as a Promising Therapy for Infertility.从多能干细胞进行体外配子分化作为一种有前景的不孕症治疗方法。
Stem Cells Dev. 2016 Apr 1;25(7):509-21. doi: 10.1089/scd.2015.0230.
7
Use of Very Small Embryonic-Like Stem Cells to Avoid Legal, Ethical, and Safety Issues Associated With Oncofertility.使用极小胚胎样干细胞以避免与肿瘤生育力相关的法律、伦理和安全问题。
JAMA Oncol. 2016 May 1;2(5):689. doi: 10.1001/jamaoncol.2016.1002.
8
Use of Very Small Embryonic-Like Stem Cells to Avoid Legal, Ethical, and Safety Issues Associated With Oncofertility-Reply.使用极小胚胎样干细胞以避免与肿瘤生育力相关的法律、伦理和安全问题——回复
JAMA Oncol. 2016 May 1;2(5):689-90. doi: 10.1001/jamaoncol.2016.1008.
9
Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds.通过小分子化合物从小鼠原始生殖细胞衍生而来的多能干细胞。
Stem Cells. 2015 Jan;33(1):45-55. doi: 10.1002/stem.1838.
10
Stem Cell-Derived Human Gametes: The Public Engagement Imperative.干细胞来源的人类配子:公众参与的必要性。
Trends Mol Med. 2019 Mar;25(3):165-167. doi: 10.1016/j.molmed.2019.01.005. Epub 2019 Feb 6.

引用本文的文献

1
Mitochondria derived from Stem cells modulated the biological behavior of monocyte-macrophages and inhibited inflammatory bone resorption.源自干细胞的线粒体调节单核细胞-巨噬细胞的生物学行为并抑制炎症性骨吸收。
BMC Musculoskelet Disord. 2025 Mar 22;26(1):286. doi: 10.1186/s12891-025-08529-8.
2
Organoid Ethical Typology: varieties of three-dimensional stem cell constructs and the many issues they raise in bioethics.类器官伦理类型学:三维干细胞构建体的种类及其在生物伦理学中引发的诸多问题。
Biol Cell. 2025 Jan;117(1):e2400093. doi: 10.1111/boc.202400093.
3
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.
探索诱导多能干细胞在癌症研究和治疗中的广阔前景。
Mol Cancer. 2023 Nov 28;22(1):189. doi: 10.1186/s12943-023-01873-0.
4
Public attitudes in Japan toward the creation and use of gametes derived from human-induced pluripotent stem cells.日本公众对源自人诱导多能干细胞的配子的创造和使用的态度。
Future Sci OA. 2021 Oct 22;7(10):FSO755. doi: 10.2144/fsoa-2021-0066. eCollection 2021 Dec.
5
Germ Cell Derivation from Pluripotent Stem Cells for Understanding In Vitro Gametogenesis.多能干细胞来源生殖细胞用于体外配子发生研究。
Cells. 2021 Jul 26;10(8):1889. doi: 10.3390/cells10081889.
6
Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells.缺氧作为多能干细胞重编程和分化为内皮细胞的驱动力。
Biomolecules. 2020 Nov 29;10(12):1614. doi: 10.3390/biom10121614.
7
Impact of Ovarian Aging in Reproduction: From Telomeres and Mice Models to Ovarian Rejuvenation.卵巢衰老对生殖的影响:从端粒和小鼠模型到卵巢 rejuvenation。
Yale J Biol Med. 2020 Sep 30;93(4):561-569. eCollection 2020 Sep.
8
Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations.诱导多能干细胞(iPSCs)的研究和治疗:社会、法律和伦理方面的考虑。
Stem Cell Res Ther. 2019 Nov 21;10(1):341. doi: 10.1186/s13287-019-1455-y.
9
Canada's Pragmatic Reforms in Support of Research.加拿大支持科研的务实改革。
Front Med (Lausanne). 2019 Jul 10;6:157. doi: 10.3389/fmed.2019.00157. eCollection 2019.
10
Regulation of Stem Cell Technology in Malaysia: Current Status and Recommendations.马来西亚的干细胞技术监管:现状与建议。
Sci Eng Ethics. 2020 Feb;26(1):1-25. doi: 10.1007/s11948-019-00111-5. Epub 2019 May 23.