Zaribaf F, Falahi E, Barak F, Heidari M, Keshteli A H, Yazdannik A, Esmaillzadeh A
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
Eur J Clin Nutr. 2014 Apr;68(4):474-80. doi: 10.1038/ejcn.2014.5. Epub 2014 Feb 19.
BACKGROUND/OBJECTIVES: Although fish consumption has inversely been associated with several metabolic abnormalities, limited and inconsistent data have reported the relationship between fish consumption and metabolic syndrome. The aim of this study was to identify the association between fish consumption and metabolic syndrome and its components.
SUBJECTS/METHODS: In a cross-sectional study conducted on 420 Iranian female adults, usual fish consumption was assessed using a dish-based semiquantitative food frequency questionnaire (FFQ). Fasting blood samples were taken for biochemical assessment. Anthropometric and blood pressure measurements were carried out according to standard protocols. Metabolic syndrome was defined based on the National Cholesterol Education Program Adult Treatment Panel III guidelines. Multivariate logistic regression adjusted for lifestyle and dietary variables was applied to assess fish-metabolic syndrome association.
The prevalence of metabolic syndrome was 8.2%. Mean daily intake of fish was 14.4 g per day. Individuals in the highest tertile of fish intake were 65% less likely to have the metabolic syndrome than those in the lowest tertile (odds ratio: 0.35; 95% confidence interval (CI): 0.14-0.88). Controlling for potential confounders and dietary variables strengthened this association (odds ratio: 0.05; 95% CI: 0.004-0.64). After adjustment for potential cofounders, high fish intake was inversely associated with hypertriglyceridemia (odds ratio: 0.11; 95% CI: 0.01-0.85), low high-density lipoprotein cholesterol (odds ratio: 0.57; 95% CI: 0.19-0.89) and elevated blood pressure (odds ratio: 0.23; 95% CI: 0.14-0.89).
We found that increased fish intake was independently related to the lower odds of metabolic syndrome and its features. Further prospective investigations are warranted to confirm this association.
背景/目的：尽管食用鱼类与多种代谢异常呈负相关，但关于鱼类消费与代谢综合征之间关系的数据有限且不一致。本研究的目的是确定鱼类消费与代谢综合征及其组成部分之间的关联。
受试者/方法：在一项对420名伊朗成年女性进行的横断面研究中，使用基于菜肴的半定量食物频率问卷（FFQ）评估鱼类的通常消费量。采集空腹血样进行生化评估。根据标准方案进行人体测量和血压测量。代谢综合征根据美国国家胆固醇教育计划成人治疗小组第三次报告指南进行定义。应用针对生活方式和饮食变量进行调整的多变量逻辑回归来评估鱼类与代谢综合征之间的关联。
代谢综合征的患病率为8.2%。鱼类的平均每日摄入量为每天14.4克。鱼类摄入量最高三分位数的个体患代谢综合征的可能性比最低三分位数的个体低65%（优势比：0.35；95%置信区间（CI）：0.14 - 0.88）。控制潜在混杂因素和饮食变量后，这种关联得到加强（优势比：0.05；95% CI：0.004 - 0.64）。在对潜在混杂因素进行调整后,高鱼类摄入量与高甘油三酯血症呈负相关（优势比：0.11；95% CI：0.01 - 0.85）、低高密度脂蛋白胆固醇（优势比：0.57；95% CI：0.19 - 0.89）和血压升高（优势比：0.23；95% CI：0.14 - 0.89）。
我们发现鱼类摄入量增加与代谢综合征及其特征的较低发病几率独立相关。需要进一步的前瞻性研究来证实这种关联。
