Iannone Camilla, Valcárcel Juan
Centre de Regulació Genòmica (CRG), Barcelona, Spain.
Chromosoma. 2013 Dec;122(6):465-74. doi: 10.1007/s00412-013-0425-x. Epub 2013 Aug 3.
Intron removal (pre-mRNA splicing) is a necessary step for expression of most genes in higher eukaryotes. Alternative splice site selection is a prevalent mechanism that diversifies genome outputs and offers ample opportunities for gene regulation in these organisms. Pre-mRNA splicing occurs co-transcriptionally and is influenced by features in chromatin structure, including nucleosome density and epigenetic modifications. We review here the molecular mechanisms by which the reciprocal interplay between chromatin and RNA processing can contribute to alternative splicing regulation.
内含子去除（前体mRNA剪接）是高等真核生物中大多数基因表达的必要步骤。可变剪接位点选择是一种普遍存在的机制，它使基因组输出多样化，并为这些生物中的基因调控提供了充足的机会。前体mRNA剪接在转录过程中同时发生，并受染色质结构特征的影响，包括核小体密度和表观遗传修饰。我们在此综述染色质与RNA加工之间的相互作用有助于可变剪接调控的分子机制。
