Buja L Maximilian
Cardiovascular Pathology Research Laboratory, Texas Heart Institute, Houston, Texas 77030, USA.
Tex Heart Inst J. 2013;40(3):221-8.
Ongoing investigation has provided new insights into the pathobiology of myocardial ischemic injury. These include an improved understanding of the roles of the major modes of cell injury and death, including oncosis, apoptosis, and unregulated autophagy, as well as the central role of the mitochondria in the progression of myocardial ischemic injury, reperfusion injury, and myocardial conditioning. This understanding is providing insights for developing new pathophysiologic, pharmacologic, and cell-based therapies, alone or in combination with percutaneous coronary interventions, for better preservation of myocardium and reduction of morbidity and mortality rates from ischemic heart disease.
正在进行的研究为心肌缺血损伤的病理生物学提供了新的见解。这些见解包括对细胞损伤和死亡主要模式（包括肿胀性坏死、凋亡和失控性自噬）作用的更深入理解，以及线粒体在心肌缺血损伤、再灌注损伤和心肌预处理进展中的核心作用。这种理解为开发新的病理生理学、药理学和基于细胞的疗法提供了思路，这些疗法单独使用或与经皮冠状动脉介入治疗联合使用，以更好地保护心肌并降低缺血性心脏病的发病率和死亡率。
