Center for Nanoparticle Research, Institute for Basic Science, Seoul 151-742, Republic of Korea.
J Am Chem Soc. 2013 Aug 14;135(32):11704-7. doi: 10.1021/ja404695t. Epub 2013 Aug 5.
A completely atom-economical and redox-neutral catalytic amide synthesis from an alcohol and a nitrile is realized. The amide C-N bond is efficiently formed between the nitrogen atom of nitrile and the α-carbon of alcohol, with the help of an N-heterocyclic carbene-based ruthenium catalyst, without a single byproduct. A utility of the reaction was demonstrated by synthesizing (13)C or (15)N isotope-labeled amides without involvement of any separate reduction and oxidation step.
实现了一种完全原子经济性和氧化还原中性的酰胺合成方法，从醇和腈出发。在 N-杂环卡宾基钌催化剂的帮助下，腈的氮原子和醇的α-碳之间高效形成酰胺 C-N 键，没有生成任何副产物。该反应的实用性通过合成（13）C 或（15）N 同位素标记的酰胺来证明，无需涉及任何单独的还原和氧化步骤。
