Berganza Carlos J, Zhang John H
Departments of Neurosurgery and Physiology, Loma Linda University, Loma Linda California, USA.
Med Gas Res. 2013 Aug 4;3(1):18. doi: 10.1186/2045-9912-3-18.
The noble gas helium has many applications owing to its distinct physical and chemical characteristics, namely: its low density, low solubility, and high thermal conductivity. Chiefly, the abundance of studies in medicine relating to helium are concentrated in its possibility of being used as an adjunct therapy in a number of respiratory ailments such as asthma exacerbation, COPD, ARDS, croup, and bronchiolitis. Helium gas, once believed to be biologically inert, has been recently shown to be beneficial in protecting the myocardium from ischemia by various mechanisms. Though neuroprotection of brain tissue has been documented, the mechanism by which it does so has yet to be made clear. Surgeons are exploring using helium instead of carbon dioxide to insufflate the abdomen of patients undergoing laparoscopic abdominal procedures due to its superiority in preventing respiratory acidosis in patients with comorbid conditions that cause carbon dioxide retention. Newly discovered applications in Pulmonary MRI radiology and imaging of organs in very fine detail using Helium Ion Microscopy has opened exciting new possibilities for the use of helium gas in technologically advanced fields of medicine.
惰性气体氦因其独特的物理和化学特性而有许多应用,具体如下:低密度、低溶解度和高导热性。主要地,医学领域中与氦相关的大量研究集中在其作为多种呼吸系统疾病辅助治疗手段的可能性上,如哮喘加重、慢性阻塞性肺疾病(COPD)、急性呼吸窘迫综合征(ARDS)、哮吼和细支气管炎。氦气曾被认为具有生物惰性,但最近研究表明,它通过多种机制对保护心肌免受缺血损伤有益。尽管已证明氦气对脑组织有神经保护作用,但其作用机制尚不清楚。由于在预防因合并症导致二氧化碳潴留的患者发生呼吸性酸中毒方面具有优势,外科医生正在探索在腹腔镜腹部手术中使用氦气而非二氧化碳对患者腹部进行充气。氦气在肺部磁共振成像(MRI)以及使用氦离子显微镜对器官进行超精细成像方面的新应用,为氦气在先进医学技术领域的应用开辟了令人兴奋的新前景。