Lu C H, Li Y Y, Wang H X, Wang B M, Shen Y M
School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
Drug Discov Ther. 2013 Jun;7(3):101-4.
During screening of marine actinomycetes for anti-mycobacterial activity, a new phenoxazine derivative (1) was isolated, along with 6-phenazinediol (2), 6-methoxy-1-phenazinol (3), nocardamin (4), and 3-pyridinecarboxylic acid (5), from a culture of Nocardiopsis sp. 236 collected from the west Pacific. The chemical structure of 1 was established on the basis of 1D-, 2D-NMR, and HRQ-TOF MS data. All compounds were evaluated for their anti-mycobacterial activity in vitro, and only compounds 2 and 3 exhibited weak activity.
在筛选具有抗分枝杆菌活性的海洋放线菌过程中，从一株采自西太平洋的诺卡氏菌属菌株236的培养物中，分离出一种新的吩恶嗪衍生物（1），以及6 - 吩嗪二醇（2）、6 - 甲氧基 - 1 - 吩嗪醇（3）、诺卡胺（4）和3 - 吡啶羧酸（5）。基于一维、二维核磁共振以及高分辨四极杆飞行时间质谱数据确定了1的化学结构。对所有化合物进行了体外抗分枝杆菌活性评估，只有化合物2和3表现出较弱的活性。
