荷兰绵羊养殖者和农场居民中贝氏柯克斯体的血清流行率和危险因素。
Coxiella burnetii seroprevalence and risk factors in sheep farmers and farm residents in The Netherlands.
机构信息
Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Department of Small Ruminant Health, Animal Health Service (GD), Deventer, The Netherlands.
出版信息
Epidemiol Infect. 2014 Jun;142(6):1231-44. doi: 10.1017/S0950268813001726. Epub 2013 Aug 7.
In this study, Coxiella burnetii seroprevalence was assessed for dairy and non-dairy sheep farm residents in The Netherlands for 2009-2010. Risk factors for seropositivity were identified for non-dairy sheep farm residents. Participants completed farm-based and individual questionnaires. In addition, participants were tested for IgG and IgM C. burnetii antibodies using immunofluorescent assay. Risk factors were identified by univariate, multivariate logistic regression, and multivariate multilevel analyses. In dairy and non-dairy sheep farm residents, seroprevalence was 66·7% and 51·3%, respectively. Significant risk factors were cattle contact, high goat density near the farm, sheep supplied from two provinces, high frequency of refreshing stable bedding, farm started before 1990 and presence of the Blessumer breed. Most risk factors indicate current or past goat and cattle exposure, with limited factors involving sheep. Subtyping human, cattle, goat, and sheep C. burnetii strains might elucidate their role in the infection risk of sheep farm residents.
本研究评估了 2009-2010 年荷兰奶牛场和非奶牛场绵羊养殖者中感染柯克斯体的血清流行率。确定了非奶牛场绵羊养殖者血清阳性的相关风险因素。参与者填写了基于农场和个人的调查问卷。此外，还使用免疫荧光分析检测参与者 IgG 和 IgM 柯克斯体抗体。通过单变量、多变量逻辑回归和多变量多层次分析确定了风险因素。在奶牛场和非奶牛场绵羊养殖者中，血清流行率分别为 66.7%和 51.3%。显著的风险因素包括接触牛、农场附近山羊密度高、从两个省供应绵羊、频繁更换厩床垫料、农场于 1990 年前建立以及存在 Blessumer 品种。大多数风险因素表明当前或过去山羊和牛的接触，涉及绵羊的因素有限。对人类、牛、山羊和绵羊的柯克斯体菌株进行亚型分析可能阐明其在绵羊养殖者感染风险中的作用。
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