Delaram Masoumeh, Kheiri Soleiman, Hodjati Mohammad Reza
Department of Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran.
J Reprod Infertil. 2011 Jul;12(3):221-6.
Premenstrual syndrome (PMS) is a condition characterized by a number of behavioral, psychological and physical symptoms recurring cyclically during the luteal phase of the menstrual cycle. The uncertainty in the pathogenesis of PMS has led to many treatment protocols being suggested as possible therapies. The present study was carried out to compare the effects of echinophora-platyloba and fennel extracts on the PMS against placebo in students of Shahrekord University of Medical Sciences in 2008.
In this single-blind randomized clinical trial, 90 students with moderate to severe PMS enrolled in the study and were randomely divided into three equal groups. The first group received echinophora-platyloba extract, the second group received fennel extracts and the third group received placebo. The severity of PMS was measured by Daily Record of Severity of Problems (DRSP) questionnaire at the end of the first and second menstrual cycles before the intervention and the results were compared with them after the intervention. Data was analyzed using Dunn, Kruskal Wallis, and Pearson correlation tests by SPSS (v. 11.5) and p < 0.05 was considered statistically significant.
There were not any significant differences in the means of premenstrual syndrome scores before the intervention among the three groups (100.8±22.1 in echinophora-platyloba group, 101.3±27.1 in fennel group and 104.3±19.5 in placebo group, p > 0.05), but the differences were significant after the intervention (49.7±23.2 in echinophora-platyloba group, 64.4±27.5 in fennel group and 79.1±28.1 in placebo group, respectively, p < 0.001). No significant differences were seen between the echinophora-platyloba and fennel groups.
The echinophora-platyloba and fennel extracts could reduce the severity of PMS. The effects of echinophora-platyloba and fennel were similar and greater than the placebo. Administration of the extracts of these herbs is suggested for relieving the signs and symptoms of PMS.
经前综合征（PMS）是一种在月经周期黄体期周期性出现一系列行为、心理和身体症状的病症。PMS发病机制的不确定性导致许多治疗方案被提议作为可能的疗法。本研究于2008年在设拉子医科大学的学生中开展，比较刺山柑和茴香提取物对PMS的影响与安慰剂的效果。
在这项单盲随机临床试验中，90名中重度PMS学生参与研究并被随机分为三组。第一组接受刺山柑提取物，第二组接受茴香提取物，第三组接受安慰剂。在干预前的第一个和第二个月经周期结束时，通过问题严重程度每日记录（DRSP）问卷测量PMS的严重程度，并将结果与干预后的结果进行比较。数据使用SPSS（v. 11.5）的邓恩检验、克鲁斯卡尔 - 沃利斯检验和皮尔逊相关检验进行分析，p < 0.05被认为具有统计学意义。
三组干预前经前综合征评分均值无显著差异（刺山柑组为100.8±22.1，茴香组为101.3±27.1，安慰剂组为104.3±19.5，p > 0.05），但干预后差异显著（刺山柑组为49.7±23.2，茴香组为64.4±27.5，安慰剂组为79.1±28.1，p < 0.001）。刺山柑组和茴香组之间未见显著差异。
刺山柑和茴香提取物可降低PMS的严重程度。刺山柑和茴香的效果相似且优于安慰剂。建议使用这些草药提取物来缓解PMS的体征和症状。
