Al-Amoudi Wael M
Department of Biology, Faculty of Applied Sciences, Umm Al-Qura University, Post Box 6055, Makkah 21955, Saudi Arabia.
Saudi J Biol Sci. 2017 May;24(4):915-924. doi: 10.1016/j.sjbs.2016.10.021. Epub 2016 Nov 5.
(Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b.w fennel oil 3 days/week for 6 weeks. The biochemical analyses of hepatic enzymes were evaluated by estimating blood biomarkers of liver and renal damage along with histological examination. The results obtained from this work showed that treating animals with SVP lead to many histopathological alterations in the liver and kidney tissues. The effect appeared in the liver tissue include leukocyte infiltrations, cytoplasmic vacuolization of the hepatocytes, fatty degeneration and congestion of blood vessels. This commonly used chemical (SVP) caused some unwanted effects on the kidney cortex which histologically observed as degeneration in renal tubules, atrophy of the glomeruli and edema. Biochemical results also revealed an abnormal increase in the enzyme level of AST, SAT, ALP, bilirubin, creatinine and urea-nitrogen, with a noticed decrease in total protein content. However, the results of treated rats with SVP plus fennel oil showed some positive histopathological changes in both the liver and kidney tissues. These results have confirmed that fennel oil has positive effects on the histological structure of the liver and kidney and the biochemical levels of AST, ALT, ALP, bilirubin, total proteins, creatinine and urea. It is concluded that fennel oil has various pharmacological properties including antioxidant, anti-cancer activity, anti-inflammatory. These valuable effects might be due to the presence of aromatic compounds -anethole. This useful properties of fennel plant could be due to its antioxidant activity that prevents the toxicity of SVP.
伞形科植物通常被称为茴香。这种草药在全球范围内广为人知，传统上用作治疗癫痫疾病、惊厥、驱风、助消化、催乳、利尿以及治疗呼吸道和胃肠道疾病的草药疗法。本研究的目的是调查茴香油对白化大鼠丙戊酸钠（SVP）毒性的可能影响。为了评估茴香油对SVP诱导的肝毒性和肾毒性的保护作用，雄性白化大鼠每周3天接受1 ml/kg体重的茴香油治疗，持续6周。通过估计肝脏和肾脏损伤的血液生物标志物以及组织学检查来评估肝酶的生化分析。这项工作获得的结果表明，用SVP治疗动物会导致肝脏和肾脏组织出现许多组织病理学改变。在肝脏组织中出现的影响包括白细胞浸润、肝细胞胞质空泡化、脂肪变性和血管充血。这种常用化学物质（SVP）对肾皮质产生了一些不良影响，组织学上表现为肾小管变性、肾小球萎缩和水肿。生化结果还显示，AST、SAT、ALP、胆红素、肌酐和尿素氮的酶水平异常升高，总蛋白含量显著降低。然而，用SVP加茴香油治疗的大鼠结果显示，肝脏和肾脏组织都有一些积极的组织病理学变化。这些结果证实，茴香油对肝脏和肾脏的组织结构以及AST、ALT、ALP、胆红素、总蛋白、肌酐和尿素的生化水平有积极影响。得出的结论是，茴香油具有多种药理特性，包括抗氧化、抗癌活性、抗炎。这些有价值的作用可能归因于芳香化合物——茴香脑的存在。茴香植物的这种有益特性可能归因于其抗氧化活性，从而预防了SVP的毒性。
