Goldacker S, Gause A M, Warnatz K
Centrum für Chronische Immmundefizienz, Universitätsklinikum Freiburg und Universität Freiburg, Breisacher Str. 117 - 2. OG, 79106, Freiburg, Deutschland.
Z Rheumatol. 2013 Sep;72(7):690-4, 696-700, 702-4. doi: 10.1007/s00393-013-1155-4.
Patients with chronic inflammatory rheumatic diseases often have an intrinsic and therapy associated increased susceptibility to infections which substantially contributes to morbidity and mortality of the patients. A large proportion of these infections are preventable by vaccination. For this reason in 2005 the standing vaccination committee (STIKO) recommended for patients with immunosuppression vaccination against pneumococcus, influenza, Haemophilus influenza b and meningococcus in addition to standard vaccinations, independent of age. Every patient should therefore be informed about a possible increase in susceptibility to infections and the recommended prevention by vaccination before implementation of immunosuppressive therapy.
患有慢性炎症性风湿性疾病的患者通常本身以及因治疗而导致对感染的易感性增加,这在很大程度上导致了患者的发病率和死亡率。这些感染中有很大一部分可通过接种疫苗预防。因此,常设疫苗接种委员会(STIKO)在2005年建议,对于免疫抑制患者,除标准疫苗接种外,还应接种针对肺炎球菌、流感、b型流感嗜血杆菌和脑膜炎球菌的疫苗,年龄不限。因此,在实施免疫抑制治疗前,应告知每位患者感染易感性可能增加以及推荐的疫苗预防措施。