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Small molecules aimed at type III secretion systems to inhibit bacterial virulence.

作者信息

Tsou Lun K, Dossa Paul D, Hang Howard C

机构信息

Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY 10065, USA.

出版信息

Medchemcomm. 2013 Jan 1;4(1):68-79. doi: 10.1039/C2MD20213A.

DOI:10.1039/C2MD20213A
PMID:23930198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3733274/
Abstract
摘要

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PLoS Genet. 2012;8(6):e1002733. doi: 10.1371/journal.pgen.1002733. Epub 2012 Jun 14.
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Interactions between the microbiota and the immune system.微生物群与免疫系统的相互作用。
Science. 2012 Jun 8;336(6086):1268-73. doi: 10.1126/science.1223490. Epub 2012 Jun 6.
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The type III secretion system as a source of novel antibacterial drug targets.III 型分泌系统作为新型抗菌药物靶点的来源。
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Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of .云南白药通过抑制 毒力基因表达和生物膜形成来减少医院获得性压疮。
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Considerations and caveats in anti-virulence drug development.抗毒力药物研发中的考量与注意事项。
Curr Opin Microbiol. 2016 Oct;33:41-46. doi: 10.1016/j.mib.2016.06.001. Epub 2016 Jun 16.
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