Tsou Lun K, Yount Jacob S, Hang Howard C
Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY 10065, USA; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Miaoli County 35053, Taiwan, ROC.
Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY 10065, USA; Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA.
Bioorg Med Chem. 2017 Jun 1;25(11):2883-2887. doi: 10.1016/j.bmc.2017.03.023. Epub 2017 Mar 10.
Increasing antibiotic resistance and beneficial effects of host microbiota has motivated the search for anti-infective agents that attenuate bacterial virulence rather than growth. For example, we discovered that specific flavonoids such as baicalein and quercetin from traditional medicinal plant extracts could attenuate Salmonella enterica serovar Typhimurium type III protein secretion and invasion of host cells. Here, we show epigallocatechin-3-gallate from green tea extracts also inhibits the activity of S. Typhimurium type III protein effectors and significantly reduces bacterial invasion into host cells. These results reveal additional dietary plant metabolites that can attenuate bacterial virulence and infection of host cells.
抗生素耐药性的增加以及宿主微生物群的有益作用促使人们寻找能减弱细菌毒力而非抑制其生长的抗感染药物。例如，我们发现传统药用植物提取物中的特定黄酮类化合物，如黄芩素和槲皮素，可减弱鼠伤寒沙门氏菌III型蛋白分泌及对宿主细胞的侵袭。在此，我们表明绿茶提取物中的表没食子儿茶素-3-没食子酸酯也能抑制鼠伤寒沙门氏菌III型蛋白效应子的活性，并显著减少细菌对宿主细胞的侵袭。这些结果揭示了其他能减弱细菌毒力及宿主细胞感染的膳食植物代谢物。
