Bjermo Helena, Darnerud Per Ola, Pearson Monika, Barbieri Heléne Enghardt, Lindroos Anna Karin, Nälsén Cecilia, Lindh Christian H, Jönsson Bo A G, Glynn Anders
Department of Risk and Benefit Assessment, National Food Agency, Uppsala, Sweden.
Mol Nutr Food Res. 2013 Dec;57(12):2206-15. doi: 10.1002/mnfr.201200845. Epub 2013 Aug 12.
In this study, food is suggested as a major source of human exposure to perfluorinated alkyl acids (PFAA). We investigated relations between serum levels of PFAA in adults and diet/lifestyle factors nationwide in Sweden.
In 2010-2011, adults (18-80 years, N = 270) recorded their diet for 4 days and answered a food frequency questionnaire. PFAA were measured in blood serum as well as v-3 fatty acids in plasma phospholipids as a biomarker for fish consumption. Higher levels of PFAA were associated with male sex, increased age, and higher education. Women reporting full breastfeeding for ≥12 months had 32-44% lower levels of perfluorooctane sulfonate, perfluorooctanoic acid, and perfluorohexane sulfonate than women who never nursed their infants full-time. Serum perfluorooctane sulfonate, perfluorononanoic acid, perfluorodecanoic acid, and perfluoroundecanoic acid were positively related to n-3 fatty acids in plasma (partial r = 0.19-0.34, p ≤ 0.05).
The relatively strong correlations between biomarkers of fish consumption and certain PFAA suggest that PFAA exposure should be taken into account in health risk and benefit assessment of fish consumption. Breastfeeding appears to be a major source of elimination of certain PFAA among women, and consequently PFAA exposure of nursed infants could be significant.
在本研究中，食物被认为是人类接触全氟烷基酸（PFAA）的主要来源。我们在瑞典全国范围内调查了成年人血清中PFAA水平与饮食/生活方式因素之间的关系。
在2010 - 2011年，成年人（18 - 80岁，N = 270）记录了他们4天的饮食情况，并回答了一份食物频率问卷。测定了血清中的PFAA以及血浆磷脂中的v - 3脂肪酸作为鱼类消费的生物标志物。较高的PFAA水平与男性、年龄增长和高等教育相关。报告全母乳喂养≥12个月的女性，其全氟辛烷磺酸、全氟辛酸和全氟己烷磺酸水平比从未进行过全时母乳喂养的女性低32 - 44%。血清全氟辛烷磺酸、全氟壬酸、全氟癸酸和全氟十一烷酸与血浆中的n - 3脂肪酸呈正相关（偏相关系数r = 0.19 - 0.34，p≤0.05）。
鱼类消费生物标志物与某些PFAA之间相对较强的相关性表明，在鱼类消费的健康风险和益处评估中应考虑PFAA暴露。母乳喂养似乎是女性消除某些PFAA的主要途径，因此，哺乳婴儿的PFAA暴露可能较为显著。
