Mahmood T, Akhtar N, Moldovan C
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Hippokratia. 2013 Jan;17(1):64-7.
Green tea and lotus hold several synergistic antioxidant compounds. This investigation aimed to assess the efficacy of green tea and green tea plus lotus vs. placebo multiple emulsions in healthy adults for controlling casual sebum secretions.
After signing informed consents, twenty-two participants were registered in a single-blinded, placebo-controlled, split-face comparative study. Group 1 participants applied a multiple emulsion formulation with green tea extract while group 2 applied a multiple emulsion with green tea plus lotus extract in a 60 days treatment course. A non-invasive photometric device (Sebumeter™) has been used for the measurement of casual sebum secretions on both sides of the face.
Steady and statistically significant reductions in sebum secretions were noted for mono (green tea) and combined treatments (green tea plus lotus) compared to placebo treatment. However, irrespective of the concentration of extracts in active formulations, green tea plus lotus combined treatment produced statistically more sound results (two-tailed p value = 0.0002) than green tea alone (two-tailed p value = 0.0060) in a 60-days treatment course.
RESULTS suggest that synergistic compounds in green tea and lotus could be a promising choice for cutaneous disorders where elevated sebum levels are involved in the pathophysiology of these disorders.
绿茶和莲花含有多种具有协同作用的抗氧化化合物。本研究旨在评估绿茶、绿茶加莲花与安慰剂多重乳液对健康成年人控制皮脂分泌的效果。
签署知情同意书后，22名参与者被纳入一项单盲、安慰剂对照、半脸比较研究。第1组参与者在60天的治疗过程中使用含绿茶提取物的多重乳液配方，第2组参与者使用含绿茶加莲花提取物的多重乳液。使用非侵入性光度测量设备（皮脂测量仪™）测量面部两侧的皮脂分泌情况。
与安慰剂治疗相比，单一（绿茶）治疗组和联合治疗组（绿茶加莲花）的皮脂分泌均出现稳定且具有统计学意义的减少。然而，在60天的治疗过程中，无论活性配方中提取物的浓度如何，绿茶加莲花联合治疗组在统计学上比单独使用绿茶组产生了更好的效果（双尾p值=0.0002）（双尾p值=0.0060）。
结果表明，绿茶和莲花中的协同化合物可能是治疗皮脂水平升高参与疾病病理生理过程的皮肤疾病的一个有前景的选择。
