帕金森病中的轻度认知障碍：当前概念综述
Mild cognitive impairment in Parkinson's disease: a review of current concepts.
作者信息
Palavra Natalie C, Naismith Sharon L, Lewis Simon J G
机构信息
Parkinson's Disease Research Clinic, Brain & Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.
出版信息
Neurol Res Int. 2013;2013:576091. doi: 10.1155/2013/576091. Epub 2013 Jul 1.
Abstract
Mild Cognitive Impairment in Parkinson's Disease (PD-MCI) is common and may be associated with accelerated progression to dementia. Considering the importance of this emerging entity, new diagnostic criteria have recently been proposed. Early recognition and accurate classification of PD-MCI could offer opportunities for novel therapeutic interventions. This review discusses current definitions for PD-MCI, the screening tools used, the pattern of cognitive deficits observed, and the predictors of cognitive decline and transition to Parkinson's Disease Dementia. Emerging biomarkers, which may aid diagnosis, are also explored and the role of novel treatment options is considered.
摘要
帕金森病轻度认知障碍（PD-MCI）很常见，可能与痴呆的加速进展有关。鉴于这一新兴实体的重要性，最近有人提出了新的诊断标准。对PD-MCI的早期识别和准确分类可为新型治疗干预提供机会。本综述讨论了PD-MCI的当前定义、所使用的筛查工具、观察到的认知缺陷模式，以及认知衰退和向帕金森病痴呆转变的预测因素。还探讨了可能有助于诊断的新兴生物标志物，并考虑了新型治疗方案的作用。
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