Loffeld R J L F, Dekkers P E P, Flens M
Department of Internal Medicine, Zaans Medisch Centrum, 210 1500 EE Zaandam, The Netherlands.
ISRN Gastroenterol. 2013 Jul 7;2013:871308. doi: 10.1155/2013/871308. Print 2013.
Introduction. Colorectal cancer (CRC) has a high incidence. Removal of adenomas, the precursor lesion, could be helpful in the prevention of cancer. Aim. To investigate the yearly incidence of CRC in consecutive years. Patients and Methods. All patients diagnosed with CRC in the years 1990 till 2010 were studied. Date of diagnosis, age at time of diagnosis, gender, and localisation of the tumour were assessed. Results. A total of 1575 incident CRC were diagnosed, 865 men (55%) and 710 women (45%). CRC occurred more often in men. In the course of the years, the occurrence of CRC increased. After exclusion of rectal cancer, the percentage of proximal cancer in the colon shows a trend towards increase in the consecutive years. In the twenty consecutive years, the population of the Zaanstreek region increased from 130.000 to 145.330. There was a significant increase of CRC in the age cohort 51-70 in the period of twenty years, while a significant decreasing incidence of cancer was seen in patients above 71 years. Conclusion. The decreasing incidence of colorectal cancer in the age cohorts above 71 years possibly reflects indirect evidence of an age-cohort effect due to removal of adenomas in these age cohorts earlier in life.
引言。结直肠癌（CRC）发病率较高。切除腺瘤这一癌前病变可能有助于预防癌症。目的。调查连续数年结直肠癌的年发病率。患者与方法。研究了1990年至2010年期间所有诊断为结直肠癌的患者。评估诊断日期、诊断时年龄、性别和肿瘤部位。结果。共诊断出1575例结直肠癌新发病例，其中男性865例（55%），女性710例（45%）。结直肠癌在男性中更常见。在这些年里，结直肠癌的发病率有所上升。排除直肠癌后，结肠近端癌的百分比在连续几年中呈上升趋势。在连续二十年中，赞斯特雷克地区的人口从13万增加到145330。在二十年期间，51 - 70岁年龄组的结直肠癌显著增加，而71岁以上患者的癌症发病率则显著下降。结论。71岁以上年龄组结直肠癌发病率下降可能间接反映了由于这些年龄组在早年切除腺瘤而产生的年龄队列效应。
