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Paraneoplastic progressive encephalomyelitis with rigidity and myoclonus associated with monoclonal B-cell lymphocytosis in the setting of longstanding methotrexate use: case report.长期使用甲氨蝶呤后伴单克隆 B 细胞淋巴细胞增多的副肿瘤性进行性脑脊髓炎伴僵硬和肌阵挛：病例报告。
Front Immunol. 2024 Oct 16;15:1436733. doi: 10.3389/fimmu.2024.1436733. eCollection 2024.
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Glycine receptor modulating antibody predicting treatable stiff-person spectrum disorders.预测可治疗的僵人综合征谱系障碍的甘氨酸受体调节抗体。
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[Progressive encephalomyelitis with rigidity and myoclonus : Stiff tongue as initial symptom].[伴有强直和肌阵挛的进行性脑脊髓炎：以舌僵硬为首发症状]
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本文引用的文献

1
Glycine receptor antibody mediated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM): a rare but treatable neurological syndrome.甘氨酸受体抗体介导的僵人综合征伴进行性脑脊髓炎（PERM）：一种罕见但可治疗的神经综合征。
Pract Neurol. 2014 Apr;14(2):123-7. doi: 10.1136/practneurol-2013-000511. Epub 2013 Apr 5.
2
Progressive encephalomyelitis with rigidity and myoclonus: the first pediatric case with glycine receptor antibodies.进行性脑脊髓炎伴僵硬和肌阵挛：首例甘氨酸受体抗体相关儿科病例。
JAMA Neurol. 2013 Apr;70(4):498-501. doi: 10.1001/jamaneurol.2013.1872.
3
Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype.甘氨酸受体自身免疫谱伴僵人综合征表型。
JAMA Neurol. 2013 Jan;70(1):44-50. doi: 10.1001/jamaneurol.2013.574.
4
Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition.中枢神经系统神经元表面抗体相关综合征：综述及识别指南。
J Neurol Neurosurg Psychiatry. 2012 Jun;83(6):638-45. doi: 10.1136/jnnp-2011-301237. Epub 2012 Mar 24.
5
Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations.甘氨酸受体抗体在进行性肌阵挛性脑脊髓炎伴僵硬和肌阵挛（PERM）中被检测到，但不在扫视性眼球震颤中被检测到。
J Neurol. 2012 Aug;259(8):1566-73. doi: 10.1007/s00415-011-6377-2. Epub 2012 Jan 4.
6
Thymoma-associated progressive encephalomyelitis with rigidity and myoclonus successfully treated with thymectomy and intravenous immunoglobulin.胸腺切除联合静脉注射免疫球蛋白成功治疗与胸腺瘤相关的进行性脑脊髓炎伴强直和肌阵挛
Eur Neurol. 2011;66(6):328-30. doi: 10.1159/000332033. Epub 2011 Nov 11.
7
Progressive encephalomyelitis with rigidity and myoclonus: glycine and NMDA receptor antibodies.进行性脑脊髓炎伴僵硬和肌阵挛：甘氨酸和 NMDA 受体抗体。
Neurology. 2011 Aug 2;77(5):439-43. doi: 10.1212/WNL.0b013e318227b176. Epub 2011 Jul 20.
8
A case of glycine-receptor antibody-associated encephalomyelitis with rigidity and myoclonus (PERM): clinical course, treatment and CSF findings.一例伴有僵硬和肌阵挛的甘氨酸受体抗体相关脑脊髓炎（PERM）：临床病程、治疗及脑脊液检查结果
J Neurol. 2011 Dec;258(12):2268-70. doi: 10.1007/s00415-011-6078-x. Epub 2011 May 4.
9
Progressive encephalomyelitis with rigidity and myoclonus: resolution after thymectomy.伴有强直和肌阵挛的进行性脑脊髓炎：胸腺切除术后缓解
Neurology. 2011 Jan 18;76(3):303-4. doi: 10.1212/WNL.0b013e318207b008.
10
Antiglycine-receptor encephalomyelitis with rigidity.抗甘氨酸受体脑炎伴僵硬。
J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1399-401. doi: 10.1136/jnnp.2010.229104. Epub 2010 Dec 10.

抗甘氨酸受体抗体介导的伴有僵硬和肌阵挛的进行性脑脊髓炎，与乳腺癌相关。

Anti-glycine receptor antibody mediated progressive encephalomyelitis with rigidity and myoclonus associated with breast cancer.

作者信息

De Blauwe Sofie N, Santens Patrick, Vanopdenbosch Ludo J

机构信息

Department of Neurology, AZ Sint Jan Brugge Oostende, 8000 Brugge, Belgium.

出版信息

Case Rep Neurol Med. 2013;2013:589154. doi: 10.1155/2013/589154. Epub 2013 Jul 10.

DOI:10.1155/2013/589154
PMID:23936697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3723061/
Abstract

We describe a 66-year-old woman who presented with a dramatic course of PERM. Anti-glycine receptor antibodies were found. She stabilized after plasma-exchange and partly recovered. Eighteen months later, a diagnosis of smouldering breast cancer with bone marrow metastasis was made. There are indications that this tumor was already present at first presentation. An overview of PERM and anti-glycine receptor antibodies is given.

摘要

我们描述了一位66岁女性，她患有严重的僵人综合征病程。检测到抗甘氨酸受体抗体。她在进行血浆置换后病情稳定，并部分恢复。18个月后，诊断为隐匿性乳腺癌伴骨髓转移。有迹象表明，该肿瘤在初次就诊时就已存在。本文对僵人综合征和抗甘氨酸受体抗体进行了综述。