抗甘氨酸受体抗体介导的伴有僵硬和肌阵挛的进行性脑脊髓炎，与乳腺癌相关。
Anti-glycine receptor antibody mediated progressive encephalomyelitis with rigidity and myoclonus associated with breast cancer.
作者信息
De Blauwe Sofie N, Santens Patrick, Vanopdenbosch Ludo J
机构信息
Department of Neurology, AZ Sint Jan Brugge Oostende, 8000 Brugge, Belgium.
出版信息
Case Rep Neurol Med. 2013;2013:589154. doi: 10.1155/2013/589154. Epub 2013 Jul 10.
Abstract
We describe a 66-year-old woman who presented with a dramatic course of PERM. Anti-glycine receptor antibodies were found. She stabilized after plasma-exchange and partly recovered. Eighteen months later, a diagnosis of smouldering breast cancer with bone marrow metastasis was made. There are indications that this tumor was already present at first presentation. An overview of PERM and anti-glycine receptor antibodies is given.
摘要
我们描述了一位66岁女性，她患有严重的僵人综合征病程。检测到抗甘氨酸受体抗体。她在进行血浆置换后病情稳定，并部分恢复。18个月后，诊断为隐匿性乳腺癌伴骨髓转移。有迹象表明，该肿瘤在初次就诊时就已存在。本文对僵人综合征和抗甘氨酸受体抗体进行了综述。
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2
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3
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Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition.中枢神经系统神经元表面抗体相关综合征：综述及识别指南。
J Neurol Neurosurg Psychiatry. 2012 Jun;83(6):638-45. doi: 10.1136/jnnp-2011-301237. Epub 2012 Mar 24.
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J Neurol. 2012 Aug;259(8):1566-73. doi: 10.1007/s00415-011-6377-2. Epub 2012 Jan 4.
6
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