Lim Rebecca Sin Mei, Flatman Sam, Dahm Markus C
Ear, Nose & Throat Department, Southern Health, Monash Medical Centre, 246 Clayton Road, Melbourne, VIC 3168, Australia.
Case Rep Otolaryngol. 2013;2013:920352. doi: 10.1155/2013/920352. Epub 2013 Jul 7.
We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.
我们举例介绍一个病例,患者为一名51岁男性,因鼻前庭脓肿继发脓毒症以及鼻黏膜脓疱疹到一家三级医院就诊。相关蜂窝织炎蔓延至面部及眼部,计算机断层扫描显示鼻窦黏膜增厚。患者接受了切开引流及鼻窦内窥镜手术。血培养及拭子检查结果显示革兰氏阴性杆菌——类鼻疽伯克霍尔德菌呈阳性。他存在多种危险因素,包括前往流行地区旅行。患者根据已发布的国家指南接受了延长抗生素治疗。类鼻疽由类鼻疽伯克霍尔德菌引起,该菌存在于澳大利亚北部和亚洲的土壤中。它通过皮肤或吸入途径传播,可导致肺炎、皮肤或软组织脓肿以及泌尿生殖系统感染。危险因素包括糖尿病、慢性肺病和酗酒。它可以以潜伏、活跃或再激活感染的形式存在。脓毒症患者的死亡率很高。类鼻疽在澳大利亚北部热带地区和泰国东北部呈地方流行,是严重社区获得性脓毒症最常见的病因。文献中还有另一例关于类鼻疽的报告,涉及眼眶蜂窝织炎和鼻窦炎。