Department of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224003, China.
Environ Toxicol Pharmacol. 2013 Nov;36(3):741-9. doi: 10.1016/j.etap.2013.07.008. Epub 2013 Jul 22.
Phthalates (PAEs) are chemical agents typically used as plasticizers in numerous industrial products. They have become ubiquitous contaminants due to their tendency to release into the environment. The present study was conducted to investigate the comparative antioxidant responses in liver of freshwater goldfish Carassius auratus injected intraperitoneally with 17 different PAEs at a concentration of 10 mg/kg for 10 days. The results indicated that these PAEs can adversely affect the antioxidant status, confirmed by the significantly inhibited activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase). Especially, the latter two enzymes constituted the most affected antioxidant enzymes after the exposure, and the lowest values were recorded for the catalase activity. The toxicity order was proposed via the integrated biomarker response, with dicyclohexyl phthalate the most toxic and diethyl phthalate the least. Overall, these findings may contribute to the risk assessments of these chemicals on aquatic species.
邻苯二甲酸酯（PAEs）是一类常用于多种工业产品的增塑剂的化学物质。由于它们有向环境中释放的趋势，因此成为了无处不在的污染物。本研究旨在探讨在腹腔注射浓度为 10mg/kg 的 17 种邻苯二甲酸酯 10 天后，淡水金鱼（Carassius auratus）肝脏中的抗氧化反应的比较。结果表明，这些邻苯二甲酸酯会对抗氧化状态产生不利影响，这一点可以通过抗氧化酶（超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶）活性的显著抑制得到证实。特别是后两种酶是暴露后受影响最严重的抗氧化酶，过氧化氢酶的活性最低。通过综合生物标志物反应提出了毒性顺序，其中邻苯二甲酸二环己酯毒性最强，邻苯二甲酸二乙酯毒性最弱。总的来说，这些发现可能有助于对这些化学物质对水生物种的风险评估。
