压力会增加青少年特应性皮炎的风险吗？韩国青少年风险行为网络调查（KYRBWS-VI）的结果。
Does stress increase the risk of atopic dermatitis in adolescents? results of the Korea Youth Risk Behavior Web-based Survey (KYRBWS-VI).
机构信息
Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea.
出版信息
PLoS One. 2013 Aug 5;8(8):e67890. doi: 10.1371/journal.pone.0067890. Print 2013.
This study investigated the relationship between level of stress in middle and high school students aged 12-18 and risk of atopic dermatitis. Data from the Sixth Korea Youth Risk Behavior Web-based Survey (KYRBWS-VI), a cross-sectional study among 74,980 students in 800 middle schools and high schools with a response rate of 97.7%, were analyzed. Ordinal logistic regression analyses were conducted to determine the relationship between stress and atopic dermatitis with severity. A total of 5,550 boys and 6,964 girls reported having been diagnosed with atopic dermatitis. Younger students were more likely to have atopic dermatitis. Interestingly, the educational level of parents was found to be associated with having atopic dermatitis and having more severe condition. In particular, girls with mothers with at least college education had a 41% higher risk of having atopic dermatitis and severe atopic condition (odds ratio (OR)) = 1.41, 95% CI, 1.22-1.63; P<0.0001) compared with those with mothers who had attended middle school at most. Similar trend was shown among both boys and girls for their father's education level. The stress level was found to be significantly associated with the risk of atopic dermatitis. Compared to boys with who reported "no stress", boys with "very high" stress had 46% higher the risk of having more severe atopic dermatitis (OR = 1.46, 95% CI, 1.20-1.78; P<0.0001), 44% higher (OR = 1.44, 95% CI, 1.19-1.73; P<0.0001) with "high" stress, and 21% higher (OR = 1.21, 95% CI, 1.00-1.45; P = 0.05) with "moderate" stress. In contrast, we found no statistically significant relationship between stress and atopic dermatitis in girls. This study suggests that stress and parents' education level were associated with atopic dermatitis. Specifically, degree of stress is positively correlated with likelihood of being diagnosed with this condition and increasing the severity.
本研究调查了 12-18 岁的中学生的压力水平与特应性皮炎风险之间的关系。这项研究是对第六次韩国青少年风险行为网络调查（KYRBWS-VI）的数据进行的分析，该调查是在 800 所中学和高中的 74980 名学生中进行的横断面研究，应答率为 97.7%。采用有序逻辑回归分析来确定压力与特应性皮炎严重程度之间的关系。共有 5550 名男生和 6964 名女生报告被诊断患有特应性皮炎。年龄较小的学生更有可能患有特应性皮炎。有趣的是，研究发现父母的教育水平与特应性皮炎和更严重的病情有关。特别是，母亲受过至少大学教育的女孩患特应性皮炎和严重特应性皮炎的风险要高 41%（比值比（OR）=1.41，95%CI，1.22-1.63；P<0.0001），而母亲只接受过中学教育的女孩患病风险为 1.00。这种趋势在男孩和女孩中都有其父亲的教育水平。研究发现压力水平与特应性皮炎的风险显著相关。与报告“无压力”的男孩相比，报告“压力非常大”的男孩患严重特应性皮炎的风险要高 46%（OR=1.46，95%CI，1.20-1.78；P<0.0001），报告“压力大”的男孩患严重特应性皮炎的风险要高 44%（OR=1.44，95%CI，1.19-1.73；P<0.0001），报告“中度压力”的男孩患严重特应性皮炎的风险要高 21%（OR=1.21，95%CI，1.00-1.45；P=0.05）。相比之下，我们没有发现压力与女孩特应性皮炎之间存在统计学上的显著关系。本研究表明，压力和父母的教育水平与特应性皮炎有关。具体来说，压力程度与被诊断患有这种疾病的可能性以及病情加重呈正相关。
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