*Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, Denton †Department of Pediatrics-Nutrition, Baylor College of Medicine, Houston, TX.
J Pediatr Gastroenterol Nutr. 2013 Dec;57(6):718-21. doi: 10.1097/MPG.0b013e3182a6993d.
There is a health disparity for obesity among Mexican Americans compared with other racial/ethnic groups. In particular, Mexican American children who are obese are likely to become obese adults. The purpose of this study was to examine traditional and nontraditional risk factors in a subset of Mexican American children before their participation in a larger clinical weight loss study.
Venous blood samples were collected from self-identified Mexican American children (12-14 years old) who were assigned to 1 of 3 weight groups based on their standardized body mass index; normal weight (N = 66), overweight (N = 23), or obese (N = 39). Serum was analyzed for interleukin-6, tumor necrosis factor-α, C-peptide, ghrelin, glucagon-like protein, gastric inhibitory polypeptide-1, glucagon, insulin, leptin, macrophage chemoattractant protein 1, and pancreatic polypeptide using a Luminex MagPix-based assay. Total cholesterol, high-density lipoprotein-cholesterol, triglycerides, and glucose were analyzed using enzymatic assays. Data were analyzed for significance using separate analysis of variance tests, with significance set at P < 0.05.
Relative to normal weight and overweight children, obese children had significantly elevated C-peptide (P < 0.0001), insulin (P < 0.0001), leptin (P < 0.0001), macrophage chemoattractant protein 1 (P = 0.005), and tumor necrosis factor-α (P = 0.006).
We observed that Mexican American children as a function of body weight had elevated serum concentrations of several biomarkers that have been linked to chronic disease development in adults. More research is needed to understand how these differences affect disease risk in adulthood.
与其他种族/族裔群体相比，墨西哥裔美国人存在肥胖健康差距。特别是肥胖的墨西哥裔美国儿童很可能成为肥胖的成年人。本研究的目的是在更大的临床减肥研究之前，检查一组墨西哥裔美国儿童的传统和非传统危险因素。
根据标准化体重指数，将自我认同的墨西哥裔美国儿童（12-14 岁）分配到 3 个体重组之一：正常体重（N=66）、超重（N=23）或肥胖（N=39）。使用 Luminex MagPix 基于测定法分析血清中的白细胞介素-6、肿瘤坏死因子-α、C 肽、ghrelin、胰高血糖素样肽、胃抑制多肽-1、胰高血糖素、胰岛素、瘦素、巨噬细胞趋化因子 1 和胰多肽。使用酶联免疫吸附测定法分析总胆固醇、高密度脂蛋白胆固醇、甘油三酯和葡萄糖。使用单独的方差分析检验对数据进行分析，显著性设置为 P<0.05。
与正常体重和超重儿童相比，肥胖儿童的 C 肽（P<0.0001）、胰岛素（P<0.0001）、瘦素（P<0.0001）、巨噬细胞趋化因子 1（P=0.005）和肿瘤坏死因子-α（P=0.006）明显升高。
我们观察到，随着体重的增加，墨西哥裔美国儿童的几种生物标志物血清浓度升高，这些标志物与成年人慢性疾病的发展有关。需要进一步研究了解这些差异如何影响成年后的疾病风险。
