HHMI and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 0651, USA.
Cancer Cell. 2013 Aug 12;24(2):143-4. doi: 10.1016/j.ccr.2013.07.016.
Inflammation is increasingly recognized as an essential component of tumor development, but the origin of tumor-associated inflammation remains largely unknown. In this issue of Cancer Cell, Pribluda and colleagues find that chronic stress initiates senescence-inflammatory response, which can promote tumorigenesis in the absence of exogenous inflammatory triggers.
炎症越来越被认为是肿瘤发展的一个重要组成部分，但肿瘤相关炎症的起源在很大程度上仍是未知的。在本期《癌细胞》杂志中，Pribluda 及其同事发现慢性应激会引发衰老-炎症反应，这种反应在没有外源性炎症触发的情况下也能促进肿瘤发生。
