Department of Ophthalmology, Mustafa Kemal University Medical Faculty, Hatay, Turkey,
Graefes Arch Clin Exp Ophthalmol. 2014 Feb;252(2):237-40. doi: 10.1007/s00417-013-2444-y. Epub 2013 Aug 17.
To evaluate the effect of mean platelet volume (MPV) on diabetic retinopathy in patients with type 2 diabetes mellitus.
In this study, ocular findings and MPV values were retrospectively reviewed in 192 patients with type 2 diabetes mellitus. The patients were classified into four groups according to ocular findings, as follows: group 1, diabetic patients without diabetic retinopathy (n = 70); group 2, diabetic patients with non-proliferative diabetic retinopathy (n = 64); group 3, diabetic patients with proliferative diabetic retinopathy (n = 58); and group 4, healthy controls (n = 100).
A significant difference was found in MPV values between groups 2 and 4 (P = 0.001), between groups 3 and 4 (P = 0.001), and between groups 1 and 4 (P = 0.004). No significant difference was found in MPV values between groups 1 and 2 (P = 0.241) and between groups 2 and 3 (P = 0.460); whereas there was a statistically significant difference between groups 1 and 3 (P = 0.015). The three diabetic groups (groups 1, 2, and 3) were compared with each other. While there was a statistically significant difference between groups 1 and 3 (P = 0.015), there was no significance between groups 2 and 3 (P = 0.46), and between group 1 and 2 (P = 0.241). Logistic regression analysis found a 1.40-fold increase in the risk of retinopathy development (OR: 1.404; P = 0.002) and a 1.46-fold increase in the risk of proliferative diabetic retinopathy (OR: 1.466; P = 0.002) as the MPV value increased.
In diabetic patients, the risk of retinopathy development increases with higher MPV values.
评估平均血小板体积（MPV）对 2 型糖尿病患者糖尿病视网膜病变的影响。
本研究回顾性分析了 192 例 2 型糖尿病患者的眼部检查结果和 MPV 值。根据眼部检查结果，患者被分为 4 组：第 1 组为无糖尿病视网膜病变的糖尿病患者（n=70）；第 2 组为非增生性糖尿病视网膜病变的糖尿病患者（n=64）；第 3 组为增生性糖尿病视网膜病变的糖尿病患者（n=58）；第 4 组为健康对照组（n=100）。
组 2 与组 4（P=0.001）、组 3 与组 4（P=0.001）、组 1 与组 4（P=0.004）之间的 MPV 值存在显著差异。组 1 与组 2（P=0.241）和组 2 与组 3（P=0.460）之间的 MPV 值无显著差异；而组 1 与组 3 之间存在统计学差异（P=0.015）。将 3 个糖尿病组（组 1、组 2 和组 3）相互比较。组 1 与组 3 之间存在统计学差异（P=0.015），组 2 与组 3 之间无显著差异（P=0.46），组 1 与组 2 之间也无显著差异（P=0.241）。Logistic 回归分析发现，随着 MPV 值的增加，视网膜病变发展的风险增加 1.40 倍（OR：1.404；P=0.002），增生性糖尿病视网膜病变的风险增加 1.46 倍（OR：1.466；P=0.002）。
在糖尿病患者中，随着 MPV 值的升高，视网膜病变发展的风险增加。
