Lady Davis Institute at the Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada.
Viruses. 2013 Aug 16;5(8):2019-42. doi: 10.3390/v5082019.
The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
核孔复合体（NPC）作为细胞核和细胞质之间的选择性屏障，负责通过调节 RNA 和蛋白质的运输来调节通讯。许多病毒病原体已经进化出不同的机制来劫持 NPC，以调节病毒蛋白、基因组甚至衣壳进出细胞核的运输，从而促进病毒复制。本综述检查了不同的策略和特定的核孔蛋白在病毒感染期间被利用的方式，以促进它们的生命周期并抑制宿主的病毒防御。
