Ma Pei, Pan Yutian, Li Wei, Sun Chongqi, Liu Jie, Xu Tongpeng, Shu Yongqian
Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
J Hematol Oncol. 2017 Feb 23;10(1):57. doi: 10.1186/s13045-017-0426-y.
Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRNAs, long noncoding RNAs, and circular RNAs. Emerging evidence shows that EV-associated ncRNAs play important roles in a wide range of diseases, particularly in cancer where they function through regulating protein expression of the pivotal genes that make contributions to tumorigenesis. Given their stability and abundance in serum, EV-associated ncRNAs can act as new diagnostic biomarkers and new therapeutic targets for cancer. Herein, we review the properties of EV-associated ncRNAs, their functions, and potential significance in cancer.
细胞外囊泡（EVs）是由多种细胞类型分泌的小膜泡，已发现其通过转移包括微小RNA、长链非编码RNA和环状RNA在内的非编码RNA（ncRNAs）参与细胞间通讯。新出现的证据表明，与EV相关的ncRNAs在多种疾病中发挥重要作用，尤其是在癌症中，它们通过调节对肿瘤发生有贡献的关键基因的蛋白质表达来发挥作用。鉴于其在血清中的稳定性和丰度，与EV相关的ncRNAs可作为癌症的新型诊断生物标志物和新型治疗靶点。在此，我们综述了与EV相关的ncRNAs的特性、功能及其在癌症中的潜在意义。
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