Department of Medical Physics and Biomedical Engineering, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Med Mycol. 2014 Jan;52(1):65-72. doi: 10.3109/13693786.2013.822996.
The shape of nanoparticles is an important determinant of their physical and chemical properties, possibly including the little-explored area of their use as antifungal agents. Therefore, we evaluated the in vitro antifungal activities of three different shapes of silver and gold nanostructures, including nanocubes, nanospheres, and nanowires, on Candida albicans, C. glabrata and C. tropicalis, using the microdilution and disk diffusion methods as per the guidelines of the Clinical and Laboratory Standards Institute. We found that silver and gold nanocubes had higher antifungal properties against the test species than nanospheres and nanowires. While some isolates were resistant to silver and gold nanospheres and nanowires, none of the isolates were resistant to silver and gold nanocubes. The occurrence of resistance is a new finding which should be further explored.
纳米粒子的形状是决定其物理和化学性质的一个重要因素，可能包括其作为抗真菌剂的应用这一尚未充分探索的领域。因此，我们使用微量稀释和圆盘扩散方法，根据临床和实验室标准协会的指导方针，评估了三种不同形状的银和金纳米结构（包括纳米立方体、纳米球和纳米线）对白色念珠菌、光滑念珠菌和热带念珠菌的体外抗真菌活性。我们发现，银和金纳米立方体对测试菌种的抗真菌特性高于纳米球和纳米线。虽然一些分离株对银和金纳米球和纳米线有耐药性，但没有分离株对银和金纳米立方体有耐药性。耐药性的发生是一个新的发现，应该进一步探索。
