通过蛋白聚糖结构释放到滑液中所衡量的对关节炎软骨代谢的治疗效果。
Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid.
作者信息
Saxne T, Heinegård D, Wollheim F A
出版信息
Ann Rheum Dis. 1986 Jun;45(6):491-7. doi: 10.1136/ard.45.6.491.
Abstract
Proteoglycans are molecules that are degraded and released from the articular cartilage into the synovial fluid early in an arthritic process. Such released proteoglycans were quantified by an enzyme linked immunosorbent assay (ELISA). The proteoglycan content in synovial fluid from patients with various knee joint arthritides was constant in two samples withdrawn five days apart. To determine if therapeutic measures were paralleled by effects directly on the articular cartilage the patients were treated with local injections of glucocorticoids. In all patients the glucocorticoids induced a reduction of the proteoglycan content in the synovial fluid, reflecting their effects on the cartilage. In two patients with spontaneous remission of their arthritis a reduction in the proteoglycan content in the synovial fluid was also noted. The quantification of proteoglycans in synovial fluid appears to have potential as a useful tool for monitoring the effects of therapy on cartilage metabolism.
摘要
蛋白聚糖是在关节炎进程早期从关节软骨降解并释放到滑液中的分子。通过酶联免疫吸附测定（ELISA）对这些释放的蛋白聚糖进行定量。在间隔五天采集的两份样本中，患有各种膝关节关节炎患者滑液中的蛋白聚糖含量是恒定的。为了确定治疗措施是否与对关节软骨的直接作用相平行，对患者进行了糖皮质激素局部注射治疗。在所有患者中，糖皮质激素均导致滑液中蛋白聚糖含量降低，这反映了它们对软骨的作用。在两名关节炎自发缓解的患者中，也观察到滑液中蛋白聚糖含量降低。滑液中蛋白聚糖的定量似乎有潜力作为监测治疗对软骨代谢影响的有用工具。
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