Mose F, Newman L P, Njunguna R, Tamooh H, John-Stewart G, Farquhar C, Kiarie J
Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya.
Int J STD AIDS. 2013 Jul;24(7):537-40. doi: 10.1177/0956462412473892. Epub 2013 Jul 19.
Self-reported condom use is a commonly collected statistic, yet its use in research studies may be inaccurate. We evaluated this statistic among women in HIV-discordant couples enrolled in a clinical trial in Nairobi, Kenya. Vaginal swabs were acquired from 125 women and tested for prostate-specific antigen (PSA), a biomarker for semen exposure, using an enzyme-linked immunosorbent assay. Ten (10%) of 98 women who reported 100% use of condoms in the previous month tested PSA positive. In a bivariate logistic regression analysis, among women who reported 100% condom use in the previous month, those with ≤8 years of school had significantly higher odds of testing PSA-positive (odds ratio [OR] = 8.39, 95% confidence interval [CI] 1.02-69.13) than women with more schooling. Our estimate may be conservative, as the ability to detect PSA may be limited to 24-48 hours after exposure. Less educated women may be a target group for counselling regarding reporting sexual behaviour in clinical trials.
自我报告的避孕套使用情况是一项常用的统计数据，但其在研究中的使用可能并不准确。我们对肯尼亚内罗毕一项临床试验中参与的HIV血清学不一致夫妇中的女性进行了该统计数据的评估。从125名女性身上采集了阴道拭子，并使用酶联免疫吸附测定法检测了前列腺特异性抗原（PSA），这是一种精液接触的生物标志物。在98名报告前一个月100%使用避孕套的女性中，有10名（10%）PSA检测呈阳性。在二元逻辑回归分析中，在前一个月报告100%使用避孕套的女性中，受教育年限≤8年的女性PSA检测呈阳性的几率（优势比[OR]=8.39，95%置信区间[CI]1.02-69.13）显著高于受教育程度更高的女性。我们的估计可能较为保守，因为检测PSA的能力可能仅限于接触后24至48小时。受教育程度较低的女性可能是临床试验中关于性行为报告咨询的目标群体。
