阴道前列腺特异性抗原（PSA）是乌干达感染艾滋病毒女性精液暴露的有用生物标志物。
Vaginal Prostate Specific Antigen (PSA) Is a Useful Biomarker of Semen Exposure Among HIV-Infected Ugandan Women.
作者信息
Woolf-King Sarah E, Muyindike Winnie, Hobbs Marcia M, Kusasira Adrine, Fatch Robin, Emenyonu Nneka, Johnson Mallory O, Hahn Judith A
机构信息
Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA.
Mbarara University of Science and Technology (MUST), Mbarara, Uganda.
出版信息
AIDS Behav. 2017 Jul;21(7):2141-2146. doi: 10.1007/s10461-016-1433-7.
The practical feasibility of using prostate specific antigen (PSA) as a biomarker of semen exposure was examined among HIV-infected Ugandan women. Vaginal fluids were obtained with self-collected swabs and a qualitative rapid test (ABAcardp30) was used to detect PSA. Trained laboratory technicians processed samples on-site and positive PSA tests were compared to self-reported unprotected vaginal sex (UVS) in the last 48 h. A total of 77 women submitted 126 samples for PSA testing at up to three study visits. Of these samples, 31 % (n = 39/126) were PSA positive, and 64 % (n = 25/39) of the positive PSA samples were accompanied by self-report of no UVS at the study visit the PSA was collected. There were no reported difficulties with specimen collection, storage, or processing. These findings provide preliminary data on high levels of misreported UVS among HIV-infected Ugandan women using practically feasible methods for PSA collection and processing.
在感染艾滋病毒的乌干达妇女中，研究了将前列腺特异性抗原（PSA）用作精液接触生物标志物的实际可行性。通过自我采集拭子获取阴道分泌物，并使用定性快速检测法（ABAcard p30）检测PSA。训练有素的实验室技术人员在现场处理样本，并将PSA检测呈阳性的结果与在过去48小时内自我报告的无保护阴道性行为（UVS）情况进行比较。共有77名妇女在多达三次的研究访视中提交了126份样本进行PSA检测。在这些样本中，31%（n = 39/126）的样本PSA呈阳性，且在采集PSA样本的研究访视中，64%（n = 25/39）的PSA阳性样本伴有未发生UVS的自我报告。未报告在样本采集、储存或处理方面存在困难。这些研究结果提供了初步数据，表明使用实际可行的PSA采集和处理方法时，感染艾滋病毒的乌干达妇女中存在大量UVS报告错误的情况。
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