Division of Nephrology and Hypertension, University of California Irvine Medical Center, Suite 400, City Tower, 101 City Drive, Orange, CA, 92868, USA,
Clin Exp Nephrol. 2014 Apr;18(2):265-8. doi: 10.1007/s10157-013-0847-z. Epub 2013 Aug 24.
Advanced chronic kidney disease (CKD) results in a constellation of dysregulation of lipid metabolism, oxidative stress, and inflammation which are causally interconnected and participate in a vicious cycle. The CKD-associated lipid disorders are marked by impaired clearance of very low density lipoprotein and chylomicrons, hypertriglyceridemia, formation of small dense low-density lipoprotein (LDL), oxidative modification of LDL, intermediate density lipoprotein and chylomicron remnants, and high-density lipoprotein deficiency and dysfunction. This review provides a brief overview of the role of CKD-induced lipid disorders in the pathogenesis of oxidative stress, inflammation, cardiovascular disease, impaired exercise capacity, cachexia and wasting syndrome.
晚期慢性肾脏病（CKD）导致脂质代谢、氧化应激和炎症的失调，这些失调相互因果关联，并形成恶性循环。CKD 相关的脂质异常表现为极低密度脂蛋白和乳糜微粒清除受损、高甘油三酯血症、小而密 LDL 的形成、LDL、中间密度脂蛋白和乳糜微粒残基的氧化修饰以及高密度脂蛋白缺乏和功能障碍。本文简要综述了 CKD 引起的脂质异常在氧化应激、炎症、心血管疾病、运动能力下降、恶病质和消耗综合征发病机制中的作用。
