Charité - Universitätsmedizin Berlin, Medical School, Department of Radiology, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.
Eur Radiol. 2014 Jan;24(1):60-9. doi: 10.1007/s00330-013-2977-9. Epub 2013 Aug 23.
To provide an overview of recent research in fractal analysis of tissue perfusion imaging, using standard radiological and nuclear medicine imaging techniques including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) and to discuss implications for different fields of application.
A systematic review of fractal analysis for tissue perfusion imaging was performed by searching the databases MEDLINE (via PubMed), EMBASE (via Ovid) and ISI Web of Science.
Thirty-seven eligible studies were identified. Fractal analysis was performed on perfusion imaging of tumours, lung, myocardium, kidney, skeletal muscle and cerebral diseases. Clinically, different aspects of tumour perfusion and cerebral diseases were successfully evaluated including detection and classification. In physiological settings, it was shown that perfusion under different conditions and in various organs can be properly described using fractal analysis.
Fractal analysis is a suitable method for quantifying heterogeneity from radiological and nuclear medicine perfusion images under a variety of conditions and in different organs. Further research is required to exploit physiologically proven fractal behaviour in the clinical setting.
• Fractal analysis of perfusion images can be successfully performed. • Tumour, pulmonary, myocardial, renal, skeletal muscle and cerebral perfusion have already been examined. • Clinical applications of fractal analysis include tumour and brain perfusion assessment. • Fractal analysis is a suitable method for quantifying perfusion heterogeneity. • Fractal analysis requires further research concerning the development of clinical applications.
利用标准放射学和核医学成像技术，包括计算机断层扫描（CT）、磁共振成像（MRI）、超声、正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT），提供组织灌注成像分形分析的最新研究概述，并讨论其在不同应用领域的意义。
通过搜索 MEDLINE（通过 PubMed）、EMBASE（通过 Ovid）和 ISI Web of Science 数据库，对组织灌注成像的分形分析进行了系统评价。
确定了 37 项符合条件的研究。分形分析应用于肿瘤、肺、心肌、肾、骨骼肌和脑部疾病的灌注成像。临床上，成功评估了肿瘤灌注和脑部疾病的不同方面，包括检测和分类。在生理环境下，表明可以使用分形分析适当描述不同条件和不同器官的灌注。
分形分析是一种适用于定量描述各种条件下和不同器官的放射学和核医学灌注图像异质性的方法。需要进一步研究以在临床环境中利用已证明具有生理意义的分形行为。
• 可以成功地对灌注图像进行分形分析。• 已经检查了肿瘤、肺部、心肌、肾脏、骨骼肌和大脑的灌注。• 分形分析的临床应用包括肿瘤和大脑灌注评估。• 分形分析是一种定量灌注异质性的合适方法。• 分形分析需要进一步研究以开发临床应用。
