Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Pettenkoferstr. 8a, 80336, Munich, Germany.
Int J Cardiovasc Imaging. 2013 Dec;29(8):1899-908. doi: 10.1007/s10554-013-0277-8. Epub 2013 Aug 24.
To evaluate the effect of age, gender and cardiovascular risk factors on vessel wall inflammation and the calcified plaque burden in different vascular beds as assessed by PET/CT. 315 patients (mean age: 57.8 years, 123 male and 192 female) who underwent whole body 18F-FDG PET/CT examinations were included in the study. Blood pool-corrected standardised uptake value (TBR) and the calcified plaque score (CPS, grade 0-4) were determined in the thoracic and abdominal aorta, both common carotid and both iliac arteries. The following cardiovascular risk factors were documented: Age ≥65 years (n = 114), male gender (n = 123), diabetes (n = 15), hyperlipidemia (n = 62), hypertension (n = 76), body mass index (BMI) ≥ 30 (n = 38), current smoker (n = 32). Effects of risk factors on TBR and CPS in different arterial beds were assessed using multivariate regression analysis. In the thoracic aorta TBR was independently associated with age ≥65 years and male gender, CPS was independently associated with age ≥65 years, male gender, hypertension and diabetes. In the abdominal aorta, TBR was independently associated with age ≥65 years and male gender, CPS with age ≥65 years, diabetes and smoking. Independent associations in the carotid arteries were found for age ≥65 years, male gender and BMI ≥ 30 in TBR and for age ≥65 and diabetes in CPS. In the iliac arteries, TBR was independently associated with age ≥65 and CPS with age ≥65, male gender, hypertension, diabetes and smoking. Findings of this PET/CT study demonstrate that the impact of cardiovascular risk factors on vessel wall inflammation and calcified plaque burden differs across vascular territories. Overall, CPS was more closely associated with cardiovascular risk factors compared to TBR.
评估年龄、性别和心血管危险因素对不同血管床血管壁炎症和钙化斑块负担的影响，方法为使用 PET/CT 进行评估。 本研究纳入了 315 名（平均年龄：57.8 岁，123 名男性，192 名女性）接受全身 18F-FDG PET/CT 检查的患者。在胸主动脉和腹主动脉、双侧颈总动脉和双侧髂动脉中确定血池校正标准化摄取值（TBR）和钙化斑块评分（CPS，0-4 级）。记录了以下心血管危险因素：年龄≥65 岁（n=114）、男性（n=123）、糖尿病（n=15）、高脂血症（n=62）、高血压（n=76）、BMI≥30（n=38）、当前吸烟者（n=32）。使用多元回归分析评估不同动脉床中危险因素对 TBR 和 CPS 的影响。在胸主动脉中，TBR 与年龄≥65 岁和男性性别独立相关，CPS 与年龄≥65 岁、男性性别、高血压和糖尿病独立相关。在腹主动脉中，TBR 与年龄≥65 岁和男性性别独立相关，CPS 与年龄≥65 岁、糖尿病和吸烟独立相关。在颈动脉中，TBR 与年龄≥65 岁、男性性别和 BMI≥30 独立相关，CPS 与年龄≥65 岁和糖尿病独立相关。在髂动脉中，TBR 与年龄≥65 岁独立相关，CPS 与年龄≥65 岁、男性性别、高血压、糖尿病和吸烟独立相关。这项 PET/CT 研究的结果表明，心血管危险因素对血管壁炎症和钙化斑块负担的影响在不同血管区域存在差异。总体而言，CPS 与心血管危险因素的相关性比 TBR 更密切。
