INSERM U 897, Université Bordeaux Ségalen, Bordeaux cedex, France.
BMJ Open. 2013 Aug 29;3(8):e002998. doi: 10.1136/bmjopen-2013-002998.
To study the relationship between board game playing and risk of subsequent dementia in the Paquid cohort.
A prospective population-based study.
In the Bordeaux area in South Western France.
3675 non-demented participants at baseline.
The risk of dementia during the 20 years of follow-up.
Among 3675 non-demented participants at baseline, 32.2% reported regular board game playing. Eight-hundred and forty participants developed dementia during the 20 years of follow-up. The risk of dementia was 15% lower in board game players than in non-players (HR=0.85, 95% CI 0.74 to 0.99; p=0.04) after adjustment on age, gender, education and other confounders. The statistical significance disappeared after supplementary adjustment on baseline mini-mental state examination (MMSE) and depression (HR=0.96, 95% CI 0.82 to 1.12; p=0.61). However, board game players had less decline in their MMSE score during the follow-up of the cohort (β=0.011, p=0.03) and less incident depression than non-players (HR=0.84; 95% CI 0.72 to 0.98; p<0.03).
A possible beneficial effect of board game playing on the risk of dementia could be mediated by less cognitive decline and less depression in elderly board game players.
在 Paquid 队列中研究玩棋盘游戏与随后痴呆风险之间的关系。
一项前瞻性基于人群的研究。
法国西南部波尔多地区。
基线时 3675 名非痴呆参与者。
20 年随访期间痴呆的风险。
在基线时的 3675 名非痴呆参与者中，32.2%报告经常玩棋盘游戏。在 20 年的随访期间，840 名参与者发展为痴呆。与非玩家相比，玩家痴呆的风险降低了 15%（HR=0.85，95%CI 0.74 至 0.99；p=0.04），在调整年龄、性别、教育和其他混杂因素后。在补充调整基线简易精神状态检查（MMSE）和抑郁（HR=0.96，95%CI 0.82 至 1.12；p=0.61）后，统计学意义消失。然而，在队列的随访期间，玩家的 MMSE 评分下降幅度较小（β=0.011，p=0.03），且发生抑郁的风险低于非玩家（HR=0.84；95%CI 0.72 至 0.98；p<0.03）。
玩棋盘游戏对痴呆风险的可能有益影响可能通过老年棋盘游戏玩家认知能力下降较少和抑郁较少来介导。
