五种不同药用蘑菇产生的胞外生物聚合物对链脲佐菌素诱导的糖尿病大鼠的降血糖作用
Hypoglycemic Effects of Exo-biopolymers Produced by Five Different Medicinal Mushrooms in STZ-induced Diabetic Rats.
作者信息
Yang Byung-Keun, Kim Guk-Nam, Jeong Yong-Tae, Jeong Hun, Mehta Pradeep, Song Chi-Hyun
机构信息
Research Center for Processing & Application of Agricultural Products, Daegu University, Gyungsan, Gyungbuk 712-714, Korea.
出版信息
Mycobiology. 2008 Mar;36(1):45-9. doi: 10.4489/MYCO.2008.36.1.045. Epub 2008 Mar 31.
Hypoglycemic effects of exo-biopolymers (EBP) produced by submerged mycelial cultures of Coriolus versicolor, Cordyceps sinensis, Paecilomyces japonica, Armillariella mellea, and Fomes fomentarius were investigated in streptozotocin (STZ)-induced diabetic rats. The rats from each experimental group were orally administered with EBPs (100 mg/kg BW) daily for 2 weeks. Though the hypoglycemic effect was achieved in all the cases, however, C. versicolor EBP proved as the most potent one. The administration of the C. versicolor EBP substantially reduced (29.9%) the plasma glucose level as compared to the saline administered group (control). It also reduced the plasma total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) levels by 9.22, 23.83, 16.93, and 27.31%, respectively. The sugar and amino acid compositions of this EBP were also analyzed in detail.
研究了云芝、冬虫夏草、日本拟青霉、蜜环菌和层孔菌深层菌丝体培养产生的胞外生物聚合物（EBP）对链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖作用。每个实验组的大鼠每天口服EBP（100 mg/kg体重），持续2周。虽然所有情况下均实现了降血糖效果，但云芝EBP被证明是最有效的。与生理盐水给药组（对照组）相比，云芝EBP的给药显著降低了（29.9%）血浆葡萄糖水平。它还分别使血浆总胆固醇（TC）、甘油三酯（TG）、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平降低了9.22%、23.83%、16.93%和27.31%。还详细分析了这种EBP的糖和氨基酸组成。
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